EXTRAINTESTINAL MANIFESTATIONS IN INFLAMMATORY BOWEL DISEASE - RESULTS FROM NORTH-EASTERN ROMANIA

Authors

  • Anca CORDONEANU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Elena REZUȘ “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Otilia GAVRILESCU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Mihaela DRANGA “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Cristina CIJEVSCHI-PRELIPCEAN “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Cătălina MIHAI “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Keywords:

INFLAMMATORY BOWEL DISEASE, CROHN'S DISEASE, ULCERATIVE COLITIS, ARTICULAR MANIFESTATIONS, EX-TRAINTESTINAL MANIFESTATIONS

Abstract

EXTRAINTESTINAL MANIFESTATIONS IN INFLAMMATORY BOWEL DISEASE - RESULTS FROM NORTH-EASTERN ROMANIA (Abstract): The presence of extraintesti-nal manifestations (EIM) in inflammatory bowel disease (IBD) is a common and well-known finding. Material and methods: Using the national database IBD Prospect, we conducted a prospective case-control study that included 325 patients diagnosed with Crohn's disease (CD) or ulcerative colitis (UC). Between these cases, 81 (24.92%) were classified in the group CD, 242 (74.46%) having UC and 2 cases (0.62%) were classified as having undiffer-entiated colitis. Among them, 30 patients (9,23%) had EIM including 24 cases of articular manifestations. Regarding joint events, we found 5 cases of arthritis, 10 cases having axial manifestations like sacroiliitis or ankylosing spondylitis and 9 cases of multiple EIM includ-ing articular damage. Results: In both study arms, articular manifestations occupy the first place into EIM (14/17 CD vs. 10/13 UC, 82.35% vs. 76.92%, p=0.927). Into the CD group, joint manifestations first correlated with the ileo-colonic form of CD (8/14; 57,14%) fol-lowed by the colonic involvement (4/14; 28,57%). Into the UC arm, joint damage was asso-ciated with an extended colonic involvement (4/10; 40%) followed by proctitis and left side colitis. Both groups of patients with articular manifestations were associated with a moderate form of IBD activity - 10/14 CD vs. 5/10 UC (71.43% vs. 50%, p = 0.199). Conclusions: Most patients included in this study and having EIM belong to CD phenotype. Articular manifestations occurred at a higher frequency in patients with CD as compared to those di-agnosed with UC. The most common articular manifestation is the axial involvement, fol-lowed by peripheral arthritis.

References

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Additional Files

Published

2017-09-30

Issue

Vol. 121 No. 3 (2017): The Medical-Surgical Journal

Section

INTERNAL MEDICINE - PEDIATRICS

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