MOLECULAR AND CELL BIOLOGY TRANSLATIONAL RESEARCHES IN THE MANAGEMENT OF ORAL PREMALIGNANT LESIONS
Abstract
Traditionally, according to international
standards, research in general and implicitly
medical research is divided into two
categories: basic and applied. Basic medical
research is focused on better or fuller
understanding of both normal cellular and
molecular mechanisms as well as those of
different diseases, the findings not being
always developed into useful clinical applications.
Applied research is directed towards
a specific aim and/or solving a problem,
such as new therapies and/or diagnostic
methods, etc.
References
2. Emmert-Buck MR. Translational research: from biological discovery to public benefit (or not). Ad-vances in Biology 2014; (2014): 1-20.
3. Carnelio S, Rodrigues GS, Shenoy R, Fernandes D. A brief review of common oral premalignant lesions with emphasis on their management and cancer prevention. Indian J Surg 2018; 73(4): 256-261.
4. Mehrotra R, Pandya S, Chaudhary AK, et al. Prevalence of oral premalignant and malignant lesions at a tertiary level hospital in Allahabad, India. Asian Pac J Cancer Prev 2016; 9(2): 263-265.
5. Abdulmajeed AA, Farah CS. Can immunohistochemistry serve as an alternative to subjective histo-pathological diagnosis of oral epithelial dysplasia? Biomark Cancer 2016; 5: 49-60.
6. Oliveira Miranda A, Miranda Ferrari T, Leite T, et al. Actinic Cheilitis: Clinical Characteristics Observed in 75 Patients and a Summary of the Literature of This Often-Neglected Premalignant Dis-order. IJCM 2014; 5: 1337-1344.
7. Lotfi A, Mohammadi G, Tavassoli A, et al. Serum levels of MMP9 and MMP2 in patients with oral squamous cell carcinoma. Asian Pac J Cancer Prev 2015; 16(4): 1327-1330.
8. Villa A, Gohel A. Oral potentially malignant disorders in a large dental population. J Appl Oral Sci 2014; 22(6): 473-476.
9. Nair DR, Pruthy R, Pawar U, Chaturvedi P. Oral cancer: Premalignant conditions and screening-an update. J Cancer Res Ther 2012; 8(Suppl 1): S57-66.
10. Jin G. Using biomarkers to detect oral cancer holds potential for saving lives when the cancer is most curable. Biomark Med 2015; 4(6): 835-838.
11. Messadi DV. Diagnostic aids for detection of oral precancerous conditions. Int J Oral Sci 2016; 5(2): 59-65.
12. Sergei I. Grivennikov, Florian R. Greten, Michael Karin. Immunity, inflammation, and cancer. Cell 2017; 140(6): 883-899.
13. Coursaget P. Viruses associated with skin and mucosal cancers. Presse Med 2014; 43 (12P2): e401-e403.
14. Gasche JA, Hoffmann J, Boland CR, Goel A. Interleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cells. Int J Cancer 2011; 129(5): 1053-1063.
15. Landskron G, De la Fuente M, Thuwajit P, et al. Chronic inflammation and cytokines in the tumor microenvironment. J Immunol Res 2014; 2014: 1-19.
16. Aggarwal BB, Gupta SC, Sung B. Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers. Br J Pharmacol 2016; 169(8): 1672-1692.
17. Kamperos G, Nikitakis N, Sfakianou A, et al. Expression of NF-κB and IL-6 in oral precancerous and cancerous lesions: An immunohistochemical study. Med Oral Patol Oral Cir Bucal 2016; 21(1): e6–e13.
18. Juretić M, Cerović R, Belušić-Gobić M, et al. Salivary levels of TNF-α and IL-6 in patients with oral premalignant and malignant lesions. Folia Biol (Praha) 2017; 59(2): 99-102.
19. Sawant S, Chaukar D, D'Cruz A, Vaidya M. Cytokeratin as prognostic markers for human oral can-cer: immerging trends. Int J Med Biol Front 2015; 17(11): 1251-1272.
20. Johnson SD, De Costa AM, Young MR. Effect of the premalignant and tumor microenvironment on immune cell cytokine production in head and neck cancer. Cancers (Basel) 2014; 6(2): 756-770.
21. Shrestha B, Subedi S, Bayracharya D, Radhakrisnan R. Immunohistochemical expression of MMP-2 in an experimental progression model of oral cancer. JCMC 2014; 4(2): 3-8.
22. Eckert AW, Wickenhauser C, Salins PC, et al. Clinical relevance of the tumor microenvironment and immune escape of oral squamous cell carcinoma. J Transl Med 2016; 14(1): 85-90.
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