IMPACT OF ACROMEGALY ON THE CARDIOVASCULAR SYSTEM
Keywords:
ACROMEGALY, CARDIOMYOPATHY, ARRITHMIAS, HYPERTENSIONAbstract
IMPACT OF ACROMEGALY ON THE CARDIOVASCULAR SYSTEM (Abstract): Cardi-ovascular manifestations occur in 60% of patients with acromegaly. The severity of the structural and functional heart abnormalities mainly depends on the levels of growth hor-mone and insulin-like growth factor 1 and the time between disease onset and diagnosis. Long-lasting elevated hormone levels are responsible for acromegalic cardiomyopathy, val-vular disease, arrhythmias, hypertension, coronary artery disease and even congestive heart failure. We highlight the tremendous impact of hormone imbalance upon the heart structure and function in order to raise awareness upon the fact that cardiovascular disease has be-come the leading cause of mortality in patients with acromegaly. We draw attention to the fact that acromegaly is more than an endocrine disease and we emphasize the need for a mul-tidisciplinary approach of the acromegalic patient, of which the cardiologist must be part.
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