RECONSIDERING STATINS-CURRENT VIEW
Abstract
RECONSIDERING STATINS-CURRENT VIEW (Abstract): Statins are widely used in daily clinical practice for the management of dyslipidemia. There are numerous studies that have shown a pleiotropic effect of statins in chronic liver diseases. They increase nitric oxide synthesis, restore endothelial cell function and, by that, increase the number of progenitor endothelial cells which improve endothelial function. Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension by reduction of hepatic vascular resistance without adverse effects on systemic circulation and with an excellent safety profile. Simvastatin addition to standard therapy in patients with cirrhosis who recover from an acute variceal bleeding episode improves survivability. Statins modulate intrahepatic vascular tone and by that improve liver function and lack of significant hepatotoxic effects. Statins inhibit protease pathway activation, exert anti-inflammatory and immunomodulatory effects, modifying the cell activation cascade. Due to all these mechanisms, statins have antineoplastic effects.
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