GUT MICROBIOTA - THE CINDERELLA OF NEUROLOGICAL DISORDERS
Abstract
GUT MICROBIOTA: THE CINDERELLA OF NEUROLOGICAL DISORDERS (Abstract): Gut microbiota (GM) modulates local and systemic immune mediated responses therefore its imbalance might be implicated in the pathogenesis of several human disorders. The pallet is wide including gastrointestinal diseases such as inflammatory bowel disease, irritable bowel syndrome, metabolic diseases such as metabolic syndrome, types 1 and 2 diabetes, allergic disorders and certain tumors. Regarding neurological disorders, dysbiosis is implicated in the pathogenesis of neurodegenerative conditions like Alzheimer’s disease, Parkinson disease and amyotrophic lateral sclerosis. New data associate GM alterations with ischemic stroke and epilepsy. Also, a possible link between dysbiosis and myasthenia gravis is discussed. The aim was to synthetize the interaction between GM and the autoimmune system and the possible implications of this interaction in the pathogenesis of several neurological diseases, both autoimmune and non-autoimmune. These cause-effect relations open opportunities regarding potential new treatment measures.
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