IN VITRO EVALUATION OF NOVEL FUNCTIONALIZED NANOPARTICLES FOR TERAHERTZ IMAGING

Authors

  • C.T. MIHAI “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania
  • A. LUCA “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania
  • M DANCIU “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania
  • Teodora ALEXA-STRATULAT “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania
  • R. CIOBANU Technical University “Gh. Asachi” Iași
  • B.I. TAMBA “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania
  • Gabriela Dumitrița STANCIU “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania
  • Irina CIORTESCU “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania
  • Catalina MIHAI “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania
  • Gabriela STEFANESCU “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania
  • Irene Alexandra CIANGA-SPIRIDON “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania
  • Loredana UNGUREANU “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania
  • V. IANOLE “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania
  • I. CHIRILA Technical University “Gh. Asachi” Iași
  • V.L. DRUG “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania

Abstract

IN VITRO EVALUATION OF NOVEL FUNCTIONALIZED NANOPARTICLES FOR TERAHERTZ IMAGING (Abstract): Background: Early clinical diagnosis of gastric cancer is crucial for the treatment of patients, with increased healing rates being achieved by digestive endoscopy or surgery in patients with early gastric cancer. Magnetic nanoparticles (MNPs) are a major class of nanoscale materials currently under extensive development for improved diagnosis of a wide range of diseases, including cancer, cardiovascular disease and neurological disease. The nanoscale dimensions of MNPs give rise to unique magnetic properties and the ability to function on a cellular and molecular level, these characteristics making MNPs such promising contrast agents in different imaging applications. Aim: The research was focused on the development of some new nanoparticles suitable for use as contrast agents for terahertz imaging and assessment of the impact on gastric cell line AGS viability. Material and methods: Magnetite/Fe3O4 and Gd2O3 were functionalized by citric acid and carboxymethylcellulose and were tested on the standardized human gastric cell line AGS for the impact on cell viability by MTT assay. Results: Fe3O4 nanoparticles have induced a smaller amount of cytotoxicity at the first two dilutions, followed by an increase of the cytotoxic effect with the maxim effect at the dilution of 1:1. Also, the Gd2O3 stabilized in carboxymethylcellulose has presented a moderate cytotoxic impact in the range of 1:75 to 1:5 dilutions, followed by registration of a significant toxic effect at 1:1 dilution. Conclusions: The results obtained indicate that there is a high degree of tolerance to the tested nanoparticles, pointing out these nanoparticles suitable as contrast agents.

Author Biographies

  • C.T. MIHAI, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania

    Advanced Research and Development Center for Experimental Medicine (CEMEX)

  • A. LUCA, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania

    Advanced Research and Development Center for Experimental Medicine (CEMEX)

  • M DANCIU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania

    Faculty of Medicine
    Department of Morpho-Functional Sciences (I)

  • Teodora ALEXA-STRATULAT, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania

    Faculty of Medicine
    Department of Medical Specialties (III)

  • B.I. TAMBA, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania

    Advanced Research and Development Center for Experimental Medicine (CEMEX)

  • Gabriela Dumitrița STANCIU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania

    Advanced Research and Development Center for Experimental Medicine (CEMEX)

  • Irina CIORTESCU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania

    Faculty of Medicine
    Department of Medical Specialties (I)

  • Catalina MIHAI, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania

    Faculty of Medicine
    Department of Medical Specialties (I)

  • Gabriela STEFANESCU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania

    Faculty of Medicine
    Department of Medical Specialties (I)

  • Irene Alexandra CIANGA-SPIRIDON, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania

    Faculty of Medicine
    Department of Morpho-Functional Sciences (I)

  • Loredana UNGUREANU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania

    Faculty of Medicine
    Department of Morpho-Functional Sciences (I)

  • V. IANOLE, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania

    Faculty of Medicine
    Department of Morpho-Functional Sciences (I)

  • V.L. DRUG, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania

    Faculty of Medicine
    Department of Medical Specialties (I)

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Additional Files

Published

2019-03-29