REDUCTION OF SUBJECTIVE STRESS PERCEPTION IN FEMALE PATIENTS WITH AUTOIMMUNE HYPOTHYROIDISM AFTER RESTORING EUTHYROID STATUS WITH LEVOTHYROXINE TREATMENT

Authors

  • Lisandra DAMIAN “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Cristina-Mihaela GHICIUC “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Maria-Christina UNGUREANU Sapienza University of Rome, Italy
  • Francesca-Romana PATACCHIOLI Department of Physiology and Pharmacology “V. Erspamer”
  • Cătălina-Elena LUPUȘORU “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Keywords:

AUTOIMMUNE THY-ROID DISEASE, STRESS PERCEPTION, PSYCHOMETRIC

Abstract

REDUCTION OF SUBJECTIVE STRESS PERCEPTION IN FEMALE PATIENTS WITH AUTOIMMUNE HYPOTHYROIDISM AFTER RESTORING EUTHYTOID STATUS WITH LEVOTHYROXINE TREATMENT (Abstract): Autoimmune Thyroid Diseases (AITDs), comprising Graves’ Disease and Hashimoto’s Thyroiditis have a multifactorial origin and stress, as an environmental trigger, has been incriminated as the most frequent risk factor for the development of mood disorders. Also, hypothyroidism in Hashimoto’s Thyroiditis is asso-ciated with different neuro-psychiatric conditions such as concentration, memory and attention deficits, depressive mood and anxiety disorder, particularly in the female sex. Aim: to evaluate the subjective perception of stress in women with newly diagnosed autoimmune hypothyroid-ism and the influence on stress perception of restoring euthyroidism with levothyroxine (LT4) treatment. Materials and methods: we conducted a prospective study over a one-year period (October 2014 - September 2015) that included 17 female patients newly diagnosed with auto-immune hypothyroidism, with no history of psychiatric disorders or treatments and no other major ailments. Perceived stress was measured using four standardized questionnaires before and after instituting LT4 therapy. Results: All patients included in our study, with a mean age of 43.8 ± 10.8, reported a stress level in the medium range. After LT4 replacement treatment was initiated and euthyroidism was restored, subjective stress levels measured with all four questionnaires were lower compared to baseline. Furthermore, when we divided patients into subgroups, based on their reproductive status, psychometric scores of patients in the reproduc-tively active subgroup before and after LT4 treatment, were significantly lower after restaura-tion of euthyroidism, but no significant reductions were observed in the menopausal subgroup. Conclusions: further research is needed, using more objective stress measurement methods, for a more reliable determination of the impact of LT4 treatment and restauration of the euthyroid state in patients with autoimmune thyroid dysfunction.

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Additional Files

Published

2017-09-30

Issue

Section

INTERNAL MEDICINE - PEDIATRICS