INCREASING INCIDENCE OF RECURRENT CLOSTRIDIUM DIFFICILE INFECTION

Authors

  • Ioana-Florina IORDAN “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Anca-Maria ADAVIDOAIEI “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Irina-Adriana SAVU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • E NASTASE “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Florina FILIP-CIUBOTARU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Carmen MANCIUC “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Keywords:

RECURRENT CLOSTRIDIUM DIFFICILE INFECTION, VANCOMYCIN, COMORBIDITIES, MULTIDISCIPLINARY COLLABORATION

Abstract

Clostridium difficile infection continues to be a major cause of infectious enterocol-itis, commonly associated with antibiotic use. Infection can lead to relapses, reason why it is considered by clinicians a true challenge. Aim: To determine the incidence of recurrent Clos-tridium difficile infection in patients admitted to the Iasi Infectious Diseases Hospital over a six-month period. Material and methods: Of the 195 admitted patients, 46 presented for the recurrence of colitis. Data from medical records had been used to identify the patients who met the inclusion criteria. Results: Most of the 46 relapses were recorded in individuals aged over 60 with multiple associated comorbidities. The test for Clostridium difficile toxin was positive in a significant percentage of cases and the treatment consisted in the administration of vanco-mycin and normix alone or in combination, along with the treatment of comorbidities. Conclu-sions: Once a relapse occurs the risk of a second relapse is rising, the elderly being most vul-nerable. The use of antibiotics should be limited to situations where they are absolutely needed.

References

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Additional Files

Published

2017-09-30

Issue

Vol. 121 No. 3 (2017): The Medical-Surgical Journal

Section

INTERNAL MEDICINE - PEDIATRICS

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