ADVANCEMENT REGARDING THE ROLE OF ENDOTHELIUM IN ARTERIAL WALL DYSFUNCTION

Authors

  • Dragomir Nicolae SERBAN "Grigore T. Popa" University of Medicine - Iaşi, Romania
  • Lacramioara SERBAN "Grigore T. Popa" University of Medicine - Iaşi, Romania

Abstract

We do continue to investigate the cellular calcium fluxes involved in arterial smooth muscle muscle contractile activity (7, 13) and also the arterial wall dysfunction in CKD (14, 15). Although these areas are closely related to the subject of this editorial, we decided to leave aside the recent progress therein, to be more properly addressed on other occassions.

Author Biographies

  • Dragomir Nicolae SERBAN, "Grigore T. Popa" University of Medicine - Iaşi, Romania

    Department of Physiology

  • Lacramioara SERBAN, "Grigore T. Popa" University of Medicine - Iaşi, Romania

    Department of Physiology

References

1. Serban DN, Nilius B, Vanhoutte PM. The endothelial saga: the past, the present, the future. Pflugers Arch. 2010; 459(6): 787-792.
2. Hogas SM, Voroneanu L, Serban DN, Segall L, Hogas MM, Serban IL, Covic A. Methods and poten-tial biomarkers for the evaluation of endothelial dysfunction in chronic kidney disease: a critical ap-proach. J Am Soc Hypertens. 2010; 4(3): 116-127.
3. Covic A, Kanbay M, Voroneanu L, Turgut F, Serban DN, Serban IL, Goldsmith DJ. Vascular calci-fication in chronic kidney disease. Clin Sci (Lond). 2010; 119(3): 111-121.
4. Vanhoutte PM, Shimokawa H, Feletou M, Tang EH. Endothelial dysfunction and vascular disease - a thirthieth anniversary update. Acta Physiol (Oxf). 2015; doi: 10.1111/apha.12646.
5. Vanhoutte PM. Regenerated endothelium and its senescent response to aggregating platelets. Circ J. 2016; 80(4): 783-790.
6. Hurjui L, Serban IL, Oprişa C, Tucaliuc ES, Hogaş MM, Tucaliuc D, Hurjui I, Luca V, Serban DN. The importance of EDHF in endothelium-dependent relaxation increases distally in mesenteric arteries depending upon the contracting agent. Rev Med Chir Soc Med Nat Iasi. 2011; 115(1): 168-170.
7. Oprişa C, Serban IL, Hogaş MM, Tucaliuc ES, Hurjui L, Tucaliuc D, Serban DN, Mungiu OC. Rele-vance of L-type calcium channels for the non-genomic effects of estradiol and aldosterone upon con-tractile activity in isolated arteries. Rev Med Chir Soc Med Nat Iasi. 2011; 115(3): 750-755.
8. Leung SW, Vanhoutte PM. Endothelium-dependent hyperpolarization: age, gender and blood pressure, do they matter? Acta Physiol (Oxf). 2015; doi: 10.1111/apha.12628.
9. Fleming I. The factor in EDHF: Cytochrome P450 derived lipid mediators and vascular signaling. Vascul Pharmacol. 2016; doi: 10.1016/j.vph.2016.03.001.
10. Ma Y, Zhang P, Li J, Lu J, Ge J, Zhao Z, Ma X, Wan S, Yao X, Shen B. Epoxyeicosatrienoic acids act through TRPV4-TRPC1-KCa1.1 complex to induce smooth muscle membrane hyperpolarization and relaxation in human internal mammary arteries. Biochim Biophys Acta. 2015; 1852(3) :552-559.
11. Serban DN, Serban IL. Mechanisms involved in the relaxation induced by hydrogen peroxide in de-endothelised small mesenteric arteries of the rat. In: Blau N, Thony B - Pterins, folates and neuro-transmiters in molecular medicine, SPS Publications, Heilbronn, 2003, p. 70-74.
12. Garland CJ, Dora KA. EDH: Endothelium-dependent hyperpolarization and microvascular signaling. Acta Physiol (Oxf). 2016; doi: 10.1111/apha.12649.
13. Park KM, Trucillo M, Serban N, Cohen RA, Bolotina VM. Role of iPLA2 and store-operated channels in agonist-induced Ca2+ influx and constriction in cerebral, mesenteric, and carotid arteries. Am J Physiol Heart Circ Physiol. 2008; 294(3): H1183-H1187.
14. Hogas S, Ardeleanu S, Segall L, Serban DN, Serban IL, Hogas M, Apetrii M, Onofriescu M, Sascau R, Covic A. Changes in arterial stiffness following dialysis in relation to overhydration and to endo-thelial function. Int Urol Nephrol. 2012; 44(3): 897-905.
15. Busila I, Onofriescu M, Gramaticu A, Hogas S, Covic A, Florea L. Endothelial dysfunction assessed by laser Doppler post-occlusive hyperemia chronic kidney disese patients. Rev Med Chir Soc Med Nat Iasi. 2015; 119(4): 1001-1009.

Additional Files

Published

2016-06-30

Issue

Vol. 120 No. 2 (2016): The Medical-Surgical Journal

Section

EDITORIAL

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