• Irina Iuliana COSTACHE “Grigore T. Popa” University of Medicine and Pharmacy Iasi


Cardiovascular and neoplastic pathologies are two entities that cause a huge “burden” for the public health system. It is estimated that there are currently 15 million people suffering from cardiovascular disease and 14 million patients with a history of neoplastic disease, with risk factors and common biological links underlying the pathophysiological mechanisms of both entities (1).

Author Biography

Irina Iuliana COSTACHE, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine


1. Singh J, Blaes A: Shared Modifiable Risk Factors Between Cancer and CVD. Am Coll Cardiol 2017.
2. Johnson CB, Davis MK, Law A, Sulpher J. Shared Risk Factors for Cardiovascular Disease and Cancer: Implications for Preventive Health and Clinical Care in Oncology Patients. Can J Cardiol 2016; 32: 900-907.
3. Koene RJ, Prizment AE, Blaes A, Konety SH. Shared Risk Factors in Cardiovascular Disease and Cancer. Circulation 2016; 133: 1104-1114.
4. Serrano C, Cortes J, De Mattos-Arruda L, et al. Trastuzumab-related cardiotoxicity in the elderly: a role for cardiovascular risk factors. Annals of Oncology 2012; 23: 897-902.
5. Siegel, RL, Miller, KD, Jemal, A.CA Cancer J Clin 2020; 70(1): 7-30 / doi: 10.3322/caac.21590.
6. Herrmann J, Lerman A, Nicole P. Sandhu, et al. Evaluation and Management of Patients With Heart Disease and Cancer: Cardio-Oncology. Mayo Clin Proc 2014; 89 (9): 1287-1306.
7. Shank Coviello J. Cardiovascular and Cancer Risk: The Role of Cardio-oncology. J Adv Pract Oncol 2018; 9(2): 160-176.
8. Pelucchi C, Gallus S, Garavello W, Bosetti C, La Vecchia C. Cancer risk associated with alcohol and tobacco use: focus on upper aero-digestive tract and liver. Alcohol Res Health 2006; 29: 193-198.
9. Seretis A, Cividini S, Markozannes G, et al. Association between blood pressure and risk of cancer development: a systematic review and meta-analysis of observational studies. Sci Rep. 2019; 9 (1): 8565 /
10. Souza V, Silva E, Ribeiro M, Martins W. Hypertension in Patients with Cancer. Arq Bras Cardiol. 2015; 104(3): 246-252 / doi: 10.5935/abc.20150011.
11. Armstrong GT, Oeffinger KC, Chen Y, et al. Modifiable risk factors and major cardiac events among adult survivors of childhood cancer. J Clin Oncol 2013; 31: 3673-3680.
12. Armenian SH, Sun CL, Shannon T, et al. Incidence and predictors of congestive heart failure after autologous hematopoietic cell transplantation. Blood 2011; 118: 6023-6029.
13. Magura L, Blanchard R, Hope B, Beal JR, Schwartz GG, Sahmoun AE. Hypercholesterolemia and prostate cancer: a hospital-based case-control study. Cancer Causes Control 2008; 9: 259-1266.
14. Shah FD, Shukla SN, Shah PM, Patel HR, Patel PS. Significance of alterations in plasma lipid profile levels in breast cancer. Integr Cancer Ther 2008; 7(1): 33-41.
15. Takatani O, Okumoto T, Kosano H. Genesis of breast cancer in Japanese: a possible relationship between sex hormone-binding globulin (SHBG) and serum lipid components. Breast Cancer Res Treat 1991; 18: 527-529.
16. Eichholzer M, Stahelin HB, Gutzwiller F, Ludin E, Bernasconi F. Association of low plasma choles-terol with mortality for cancer at various sites in men: 17-years follow-up of the prospective Basel study. Am J Clin Nutr 2000; 71: 569-574.
17. Patel PS, Shah MH, Jha FP, et al. Alterations in plasma lipid profile patterns in head and neck cancer and oral precancerous conditions. Indian J Cancer 2004; 41: 25-31.
18. Qadir MI, Malik SA. Plasma lipid profile in gynecologic cancers. Eur J Gynaecol Oncol 2008; 29: 158-161.
19. Saylor PJ, Smith MR. Metabolic complications of androgen deprivation therapy for prostate cancer. J Urol 2009; 181: 1998-2006.
20. Bielecka-Dąbrowa A. Malignancy-Associated Dyslipidemia. Open Cardiovasc Med J 2011; 5(1): 35-40.
21. Warner M, Gustafsson JA. On estrogen, cholesterol metabolism, and breast cancer. N Engl J Med 2014; 370: 572-573.
22. Huang W, Li C, Lin C, Liang J. Long-term statin use in patients with lung cancer and dyslipidemia reduces the risk of death. Oncotarget 2016; 7(27): 42208-42215 / doi: 10.18632/ oncotarget.9906.
23. Jeong G, Lee K, Kim J, et al. Effect of Statin on Cancer Incidence: An Umbrella Systematic Review and Meta-Analysis. J Clin Med 2019; 8(6): 819 / doi: 10.3390/jcm8060819.
24. Zhou P, Li B, Liu B, Chen T, Xiao J. Prognostic role of serum total cholesterol and high-density lipoprotein cholesterol in cancer survivors: A systematic review and meta-analysis. Clinica Chimica Acta 2018; 477: 94-104.
25. Gallagher EJ, Zelenko Z, Neel BA, et al. Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia. Oncogene 2017, 36(46): 6462-6471.
26. Cedó L, Reddy S, Mato E, Blanco-Vaca F, Escolà-Gil J. HDL and LDL: Potential New Players in Breast Cancer Development. J Clin Med 2019; 8(6): 853 / doi: 10.3390/jcm8060853.
27. Zhou T, Zhan J, Fang W, et al. Serum low-density lipoprotein and low-density lipoprotein expression level at diagnosis are favorable prognostic factors in patients with small-cell lung cancer (SCLC). BMC Cancer 2017; 17(1): 269 / doi: 10.1186/s12885-017-3239-z.
28. Wettstein MS, Saba K, Umbehr MH, et al. Prognostic role of preoperative serum lipid levels in patients undergoing radical prostatectomy for clinically localized prostate cancer. Prostate 2017; 77(5): 549-556 / doi: 10.1002/pros.23296.
29. Liu YL, Qian HX, Qin L, Zhou XJ and Zhang B. Serum LDL-C and LDL-C/HDL-C ratio are posi-tively correlated to lymph node stages in males with colorectal cancer. Hepatogastroenterology 2011; 58(106): 383-387.
30. Deng H, Zhou T, Mo X, Liu C, Yin Y. Low density lipoprotein promotes lymphatic metastasis of esophageal squamous cell carcinoma and is an adverse prognostic factor. Oncol Lett 2019; 17(1): 1053-1061.
31. Liu X, Li M, Wang X, et al. Effect of serum triglyceride level on the prognosis of patients with hepa-tocellular carcinoma in the absence of cirrhosis. Lipids Health Dis 2018; 17(1): 248 / doi: 10.1186/ s12944-018-0898-y.
32. Seshasai SRK, Kaptoge S, Thompson A, et al. Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med 2011; 364(9): 829-841.
33. Tsilidis KK, Kasimis JC, Lopez DS, Ntzani EE, Ioannidis JP. Type 2 diabetes and cancer: umbrella review of meta-analyses of observational studies. BMJ 2015; 350: g7607.
34. Niederseer D, Isabelle Bracher, Stadlmayr A, et al. Association between Cardiovascular Risk and Diabetes with Colorectal Neoplasia: A Site-Specific Analysis. J Clin Med 2018; 7(12): 484 / doi: 10.3390/jcm7120484.
35. Arnold M, Pandeya N, Byrnes G, et al. Global burden of cancer attributable to high body-mass index in 2012: a population-based study. Lancet Oncol 2015; 16: 36-46.
36. Kyrgiou M, Kalliala I, Markozannes G, et al. Adiposity and cancer at major anatomical sites: umbrella review of the literature. BMJ 2017; 356: j477 / doi: 10.1136/bmj.j477.
37. Pothiwala P, Jain SK, Yaturu S. Metabolic syndrome and cancer. Metab Syndr Relat Disord 2009; 7: 279-288 / doi: 10.1089/met.2008.0065.
38. Protani M, Coory M, Martin JH. Effect of obesity on survival of women with breast cancer: systematic review and meta-analysis. Breast Cancer Res Treat 2010; 123: 627-635.
39. Arem H, Moore SC, Patel A, et al. Leisure time physical activity and mortality: a detailed pooled analysis of the dose-response relationship. JAMA Intern Med 2015; 175: 959-967.
40. Irwin ML, McTiernan A, Manson JE, et al. Physical activity and survival in postmenopausal women with breast cancer: results from the women’s health initiative. Cancer Prev Res (Phila) 2011; 4: 522-529.
41. Estruch R, Ros E, Salas-Salvadó J, et al. Primary prevention of cardiovascular disease with a Medi-terranean diet. N Engl J Med 2013; 368: 1279-1290.
42. Toledo E, Salas-Salvadó J, Donat-Vargas C, et al. Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial. JAMA Intern Med 2015; 175: 1752-1760.
43. Aykan NF. Red Meat and Colorectal Cancer. Oncol Rev 2015; 9(1): 288 / doi:10.4081/oncol. 2015. 288.
44. Murray CJ, Atkinson C, Bhalla K, et al. The state of US health, 1990-2010: burden of diseases, inju-ries, and risk factors. JAMA 2013; 310: 591-608.
45. Rehm J, Shield KD, Roerecke M, Gmel G. Modelling the impact of alcohol consumption on cardio-vascular disease mortality for comparative risk assessments: an overview. BMC Public Health 2016; 16: 363 / doi: 10.1186/s12889-016-3026-9.
46. Oeffinger KC, Mertens AC, Sklar CA, et al. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med 2006; 355: 1572-1582.
47. Armenian SH, Xu L, Ky B, et al. Cardiovascular Disease Among Survivors of Adult-Onset Cancer: A Community-Based Retrospective Cohort Study. J Clin Oncol 2016; 34: 1122-1130.
48. Abdel-Qadir H, Austin PC, Lee DS, et al. A Population-Based Study of Cardiovascular Mortality Following Early-Stage Breast Cancer. JAMA Cardiol 2017; 2: 88-93.