MEDICAL PRACTICE IN CHILDREN PRESENTING FEVER WITH PETECHIAL RASH TO AN EMERGENCY DEPARTMENT

Authors

  • Ioana DUMITRASCU-BIRIS Emergency Hospital for Children ”Louis Turcanu”-Timisoara
  • Adela CHIRITA-EMANDI Emergency Hospital for Children ”Louis Turcanu”-Timisoara
  • Imelda LAMBERT Midland Regional Hospital, Mullingar, Ireland
  • Otilia MARGINEAN University of Medicine and Pharmacy”Victor Babes”-Timisoara
  • Farhana SHARIF Royal College of Surgeons in Ireland

Abstract

Introduction: The association of fever and petechiae in children is one of the most alarming findings for a paediatrician. To quickly distinguish between benign and life-threatening conditions is challenging in many cases. We aimed to evaluate the clinical practice of children presenting with fever and petechiae as initial symptoms. Methods: 41 patients (age 3 months-11 years) presenting with fever and petechiae were identified in an Emergency Paediatric Assessment Unit over a period of 9 months. General data, symptoms and signs were assessed for each patient. The work-up consisted in: complete blood count, inflammatory tests, coagulation tests, Monospot test, nasopharyngeal rapid tests, blood culture, and cerebrospinal fluid culture where appropriate. Results: Most children were <5 years of age (70.7%). Female to male ratio was 1:2.4. The most common clinical diagnoses were: viral respiratory illness (48.8%, 20/41) and upper respiratory tract infection (17.1%, 7/41). Meningococcal disease was found in one case. CRP>6 mg/l was poorly correlated with serious illness. The following variables were strongly associated with serious illness: ill appearance, shivering, lethargy, back rigidity, ESR>50 mm/h and prolonged capillary refill time. 59%(24/41) of children were treated with antibiotics, however, at discharge 42%(10/24) of them, did not have a work-up suggestive for a bacterial illness. Conclusions: Screening for low prevalence but high morbidity conditions, as the meningococcal disease, with an extensive work-up is time and resource consuming and may lead to unmotivated antibiotic use. Larger studies are needed to change the emergency practice for management of fever and rash.

Author Biographies

  • Ioana DUMITRASCU-BIRIS, Emergency Hospital for Children ”Louis Turcanu”-Timisoara

    Paediatrics Department
    Midland Regional Hospital, Mullingar, Ireland
    Paediatrics Department

  • Adela CHIRITA-EMANDI, Emergency Hospital for Children ”Louis Turcanu”-Timisoara

    Paediatrics Department

  • Imelda LAMBERT, Midland Regional Hospital, Mullingar, Ireland

    Paediatrics Department

  • Otilia MARGINEAN, University of Medicine and Pharmacy”Victor Babes”-Timisoara

    Genetics Department
    Emergency Hospital for Children ”Louis Turcanu”-Timisoara
    Paediatrics Department

  • Farhana SHARIF, Royal College of Surgeons in Ireland

    Paediatrics Department
    Midland Regional Hospital, Mullingar, Ireland
    Paediatrics Department

References

1. Block SL. Petechiae and purpura: the ominous and the not-so-obvious? Pediatr Ann. 2014; 43(8): 297–303.
2. Block SL. Perpetually perplexing pediatric patients: it’s complicated: part 2. Pediatr Ann. 2015; 44(1): 12–17.
3. Richards C, Thimm A, Clark J, Thomson AP, Newton T, Riordan FAI. The management of fever and petechiae: collaborative studies are needed. Arch Dis Child. 2001; 85(2): 172–172.
4. Wing R, Dor MR, McQuilkin PA. Fever in the pediatric patient. Emerg Med Clin North Am. 2013; 31(4): 1073–96.
5. Klinkhammer MD, Colletti JE. Pediatric myth: fever and petechiae. CJEM. 2008; 10(5): 479–82.
6. Brogan PA, Raffles A. The management of fever and petechiae: making sense of rash decisions. Arch Dis Child. 2000; 83(6): 506–507.
7. Rajapaksa S, Starr M. Meningococcal sepsis. Aust Fam Physician.2010; 39(5): 276–278.
8. Yung AP, McDonald MI. Early clinical clues to meningococcaemia. Med J Aust. 2003; 178(3): 134–137.
9. Hsiao AL, Chen L, Baker MD. Incidence and predictors of serious bacterial infections among 57- to 180-day-old infants. Pediatrics. 2006; 117(5): 1695–1701.
10. Alpern ER, Stanley RM, Gorelick MH, Donaldson A, Knight S, Teach SJ, et al. Epidemiology of a pediatric emergency medicine research network: the PECARN Core Data Project. Pediatr Emerg Care. 2006; 22(10): 689–699.
11. Prevention and control of meningococcal disease. MMWR Recomm Rep. 2013; 62 (RR-2): 1–22.
12. Baker RC, Seguin JH, Leslie N, Gilchrist MJ, Myers MG. Fever and petechiae in children. Pediatrics. 1989; 84(6): 1051–1055.
13. Brogan PA, Raffles A. The management of fever and petechiae: making sense of rash decisions. Archives of disease in childhood. 2000; 83(6): 506–507.
14. Soult Rubio JA, Navarro González J, Olano Claret P. [Fever and petechial exanthema in children]. An Esp Pediatr. 1992; 37(5): 348–350.
15. Van den Bruel A, Aertgeerts B, Bruyninckx R, Aerts M, Buntinx F. Signs and symptoms for diagnosis of serious infections in children: a prospective study in primary care. Br J Gen Pract. 2007; 57(540): 538–546.
16. Pantell RH, Newman TB, Bernzweig J, Bergman DA, Takayama JI, Segal M, et al. Management and outcomes of care of fever in early infancy. JAMA. 2004; 291(10): 1203–1212.
17. Asseray N, Leconte C, El Kouri D, Touzé MD, Struillou L, Le Conte P, et al. [CRP in the management of bacterial infections in emergency]. Presse Med. 2005; 34(8): 561–565.
18. van der Does Y, Rood PPM, Haagsma JA, Patka P, van Gorp ECM, Limper M. Procalcitonin-guided therapy for the initiation of antibiotics in the ED: a systematic review. Am J Emerg Med. 2016; doi: 10.1016/j.ajem.2016.03.065.
19. Kardas P, Devine S, Golembesky A, Roberts C. A systematic review and meta-analysis of misuse of antibiotic therapies in the community. Int J Antimicrob Agents. 2005; 26(2): 106–113.
20. Sarna M, Ware RS, Sloots TP, Nissen MD, Grimwood K, Lambert SB. The burden of community-managed acute respiratory infections in the first 2-years of life. Pediatr Pulmonol. 2016; 26 doi: 10.1002/ppul.23480. [Epub ahead of print].

Additional Files

Published

2016-06-30

Issue

Section

INTERNAL MEDICINE - PEDIATRICS