DIETARY PATTERNS IN YOUNG AND MIDDLE-AGED SUBJECTS WITH FAMILIAL HYPERCHOLESTEROLEMIA FROM NORTH-EASTERN ROMANIA
Abstract
Familial hypercholesterolemia (FH) is a genetic autosomal dominant disease that is characterized by very high values of low-density lipoproteins. An unbalanced diet associated with FH will increase the cardiovascular risk of fatal and non-fatal events. Material and methods: 32 patients with FH were admitted in the Cardiovascular Rehabilitation Clinic from Iasi Clinical Rehabilitation Hospital between 1st December 2020, and 31st March 2022. Dutch Lipid Clinic Network score was the instrument used for the patient’s diagnosis. Nutritional assessment was evaluated through a validated food frequency questionnaire. Results: In our study, we have observed that men diagnosed with FH eat more chicken meat, fried food, and fast food, while women have a more balanced diet, which includes vegetables and fruits. Regarding the blood tests, we noticed higher values of triglycerides and uric acid in males when compared to women. Moreover, the HDL cholesterol level was higher in women. Regardless of gender, the subjects with FH lack in eating dairy products. Conclusions: As far as we know, this is the first study that evaluates the gender-related eating habits of young and middle-aged patients with FH. The information obtained can form the framework for the implementation of active and comprehensive prevention measures in order to increase the awareness of the disease.
References
2. Moderators, de Ferranti SD, Kazi DS, Bibbins-Domingo K, et al . Perspectives on Identifying and Treating Familial Hypercholesterolemia in Childhood. Clin Chem 2021; 67(10): 1312-1317 / doi: 10.1093/clinchem/hvab157.
3. Barbir M, Breen J, Neves E, Priestley-Barnham L, Lazem F, Grocott-Mason R. Diagnosis, manage-ment and prognosis of familial hypercholesterolemia in a UK tertiary cardiac centre. Clinical Lipidology and Metabolic Disorders 2019; 14(1): 1-10 / doi: 10.1080/ 17584299. 2019.1587877.
4. Sturm AC, Knowles JW, Gidding SS, et al . Convened by the Familial Hypercholesterolemia Founda-tion. Clinical Genetic Testing for Familial Hypercholesterolemia: JACC Scientific Expert Panel. J Am Coll Cardiol 2018; 72(6): 662-680 / doi: 10.1016/j.jacc.2018.05.044.
5. Santos RD. Screening and management of familial hypercholesterolemia. Curr Opin Cardiol. 2019; 34(5): 526-530 / doi: 10.1097/HCO.0000000000000660.
6. Haralambos K, Whatley SD, Edwards R, et al. Clinical experience of scoring criteria for Familial Hypercholesterolemia (FH) genetic testing in Wales. Atherosclerosis 2015; 240(1): 190-196 / doi: 10.1016/j.atherosclerosis.2015.03.003.
7. Liberopoulos E, Rizos C, Skoumas I, et al. Gender Differences in Familial Hyper-cholesterolemia: Insight From the HELLAS-FH Registry. Circulation 2018; 138: A12838.
8. Borg S, Bork CS, Skjelbo Nielsen MR, et al. Lipids, lipoproteins and prevalence of familial hyper-cholesterolemia in the Faroe Islands Results from a nationwide laboratory database. Atherosclerosis Plus 2022; 48: 55-59 / doi: 10.1016/ j.athplu.2022.03.004.
9. Iyen B, Qureshi N, Weng S, et al. Sex differences in cardiovascular morbidity associated with familial hypercholesterolemia: A retrospective cohort study of the UK Simon Broome register linked to national hospital records. Atherosclerosis 2020; 315: 131-137 / doi: 10.1016/j.atherosclerosis. 2020. 10.895.
10. Wang X, Magkos F, Mittendorfer B. Sex differences in lipid and lipoprotein metabolism: it's not just about sex hormones. J Clin Endocrinol Metab 2011; 96(4): 885-893 / doi: 10.1210/ jc.2010-2061.
11. Grzymisławska M, Puch EA, Zawada A, Grzymisławski M. Do nutritional behaviors depend on biological sex and cultural gender? Adv Clin Exp Med 2020; 29(1): 165-172 / doi: 10.17219/acem/ 111817.
12. Masella R, Malorni W. Gender-related differences in dietary habits. CMI 2017; 11(2): 59-62 / doi: 10.7175/cmi.v11i2.1313
13. Nasreddine L, Chamieh MC, Ayoub J, Hwalla N, Sibai AM, Naja F. Sex disparities in dietary intake across the lifespan: the case of Lebanon. Nutr J 2020; 19(1): 24 / doi: 10.1186/s12937-020-00543-x.
14. Heuer T, Krems C, Moon K, Brombach C, Hoffmann I. Food consumption of adults in Germany: results of the German National Nutrition Survey II based on diet history interviews. Br J Nutr 2015; 113(10): 1603-1614 / doi:10.1017/S0007114515000744.

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