THE IMPACT OF ESBL-PRODUCING ENTEROBACTERALES: AN OLD STORY WITH NEW PERSPECTIVES

  • Ionela-Larisa MIFTODE “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Aida BADESCU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Egidia MIFTODE “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • C. PREPELIUC “Sf. Parascheva” Clinical Hospital of Infectious Diseases, Iasi
  • Olivia Simona DORNEANU “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Abstract

Antibiotic resistance represents a global crisis, one of the biggest challenges that humanity is facing. In addition to the SARS-Cov-2 pandemic, we are currently witnessing another, more devastating pandemic of multidrug-resistant micro-organisms, not only in hospitals but also in the community. Material and methods: we aimed to analyze the incidence and implications of urinary isolated, extended-spectrum β-lactamase-producing (ESBL+) Enterobacterales, from patients admitted between 01/01/2018 and  31/12/2018. Results: the main identified pathogen was Escherichia coli, accounting for 67.3% of all cases; the ESBL-production rate was 26.5%, with E. coli and Klebsiella pneumoniae emerging as leading etiologies. Mean age was significantly higher for patients with ESBL+ isolates (57.6 vs.  65.1 years, p<0.0001), while urinary catheterization was more frequently associated with ESBL+ strains (21.8% ESBL+ vs.  6.2% ESBL-, p<0.0001). As anticipated, antibiotic susceptibility was significantly influenced both by ESBL production and urinary catheterization, except for nitrofurantoin and fosfomycin. Conclusions: comprehensive approach  of the local antibiotic susceptibility profile can facilitate the choice of a proper therapeutic management, based on regional particularities of an East European country.

Author Biographies

Ionela-Larisa MIFTODE, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Medical Specialties (II)
“Sf. Parascheva” Clinical Hospital of Infectious Diseases, Iasi

Aida BADESCU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Preventive Medicine and Interdisciplinarity
“Sf. Parascheva” Clinical Hospital of Infectious Diseases, Iasi

Egidia MIFTODE, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Medical Specialties (II)
 “Sf. Parascheva” Clinical Hospital of Infectious Diseases, Iasi

Olivia Simona DORNEANU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Preventive Medicine and Interdisciplinarity
“Sf. Parascheva” Clinical Hospital of Infectious Diseases, Iasi

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Published
2022-06-30
Section
INTERNAL MEDICINE - PEDIATRICS