THE RELEVANCE OF CYTOLOGICAL DIAGNOSTIC IN THE MAMMARY GLAND CANCER
Abstract
Breast cancer is the second leading cause of cancer death in women, while in Eastern Europe the most common form of diagnosed cancer. Out of the multiple possibilities of early detection of mammary neoplasia that have been elaborated, only mammography has proved to be a simple, efficient method and of a high sensitivity, almost 90% However, the cytological confirmation of diagnosis allows us to perform the preoperative radiotherapy treatment or poly chemotherapy. Material and methods: we analyzed the informative value of these diagnosis methods in stage I mammary gland cancer (MGC). In this way, in the present paper we demonstrated that collecting samples through fine-needle aspiration biopsy allows the cytological confirmation of the diagnosis of stage I MGC in 30.7% cases. Results and discussion: In stage I MGC young patients, under 35 years, the cytological confirmation rate is 22.2% and is lower as compared to the cytological confirmation rate in patients older than 35 years which is 37.9% Also, for a tumor diameter < 0.5 cm, the prevalence of cytological confirmation was only 10.3%, while for the diameter of 0.6 – 1.0 cm the cytological confirmation was around 40.0%. Therefore, in order to improve the cytological diagnosis confirmation rate the tumor biopsy through the USG of the mammary glands is required. Moreover, the cytological investigation of the smear obtained by the first and second puncture was instrumental in confirming the diagnosis in 41.3% and 17.4% cases; the subsequent repetition of the punctures was not useful as it helped to confirmation of the diagnosis only in 9.3% cases. The frequency of diagnosis cytological confirmation depends on the tumor histopathological form and type of growth. Conclusions: Thus, the lowest prevalence was in the mixed forms - 12.5% cases, lobular cancer - 24.4% cases, while regarding the type of growth, for the rare forms the cytological confirmation rate was 7.7% and 31.5% cases for the schiros growth type.
References
2. Xuezheng Sun, Rupninder Sandhu, Jonine D. Figueroa, Gretchen L. Gierach, Mark E. Sherman, and Melissa A. Troester Benign Breast Tissue Composition in Breast Cancer Patients: Association with Risk Factors, Clinical Variables, and Gene Expression. Cancer Epidemiology, Biomarkers and Prevention, 2014, 23, 2810.
3. Colleoni M., Goldhirsch A., Rotmensz N. Prognostic role of the extend of peritumoral vascular inva-sion in operable breast cancer. European Society for Med. Oncology, 2007.
4. Attiqua M., Nadeem Q., Vlastos G. Prognostic factors in node-negative breast cancer. Ann Surg 2002; 1: 10-26.
5. Westenend P. J, Meurs C. J, Damhuis R. A: Tumor size and vascular invasion predict distant metastasis in stage I breast cancer. Grad distinguishes early and late metastasis. J Clin Pathol 2005; 58(2): 196-201.
6. Curiglino G., Viale G., Bagnardi V. Clinical relevance of HER-2 over expression amplification in patients with small tumor size (pTla-c) and node-negative breast cancer. J Clinic Oncol 2009; 18(Suppl 1): S41.
7. Leitner S.P., Swerh A.S., Weinberger D. et al Predictors of recurrence for patients with small (one centimeter or less) localized breast cancer (Tla, bN0M0), Cancer 1995; 76(11): 2266-2274.
8. Gonzalez-Angulo AM, Hortobagyi GN, Esteva FJ. Adjuvant therapy with trastuzumab for HER2/neu-positive breast cancer. Oncologist 2006; 11(8): 857-867.
9. Dowsett M, Dunbier AK. Emerging biomarkers and new understanding of traditional markers in personalized therapy for breast cancer. Clin Cancer Res 2008; 14: 8019- 8026.
10. Early Breast Cancer Trial Lists Collaborative Group. Systemic treatment of early breast cancer by hormonal, cyto toxic or immune therapy: 133 randomized trials involving 31.0 recurrence and 24,000 deaths among 75,000 women. Lancet 1992; 339: 71-85.
11. Hayes D. Prognostic and predictive factors revisited. Breast 2005; 14(Suppl 1): S6.
Additional Files
Published
Issue
Section
License
COPYRIGHT
Once an article is accepted for publication, MSJ requests a transfer of copyrights for published articles.
COPYRIGHT TRANSFER FORM FOR
REVISTA MEDICO-CHIRURGICALĂ A SOCIETĂȚII DE MEDICI ȘI NATURALIȘTI DIN IAȘI /
THE MEDICAL-SURGICAL JOURNAL OF THE SOCIETY OF PHYSICIANS AND NATURALISTS FROM IASI
We, the undersigned authors of the manuscript entitled
_____________________________________________________________________________________
_____________________________________________________________________________________
warrant that this manuscript, which is submitted for publication in the REVISTA MEDICO-CHIRURGICALĂ, has not been published and it is not under consideration for publication in another journal.
- we give the consent for publication in the REVISTA MEDICO-CHIRURGICALĂ, in printed and electronic format and we transfer unconditioned and complete the copyright of this manuscript to the REVISTA MEDICO-CHIRURGICALĂ, in the event of its acceptance.
- the manuscript does not break the intellectual property rights of any other person.
- we have read the submitted version of the manuscript and we are fully responsible for the content.
Names and signatures of authors / copyright owners (the following sequence is the authorship of the article):
- ______________________________/_________________________
- ______________________________/_________________________
- ______________________________/_________________________
N.B. All the authors must sign this form
