• Ana Maria ZBANCIOC “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • B. SATHYAMURTHY Ramaiah College of Arts, Science and Commerce, Bangalore, India
  • Gabriela TATARINGA “Grigore T. Popa” University of Medicine and Pharmacy Iasi


Aim: In this study, we performed the evaluation of anti-Dengue potential of some acetophenone derivatives and diazine with dihydroxyacetophenone skeleton derivatives, using molecular docking approach, as potential candidates for anti-dengue virus drug discovery. Material and methods: For this study 20 synthetic ligands were used. Docking studies were conducting using iGEMDOCK (Generic Evolutionary Method for molecular Docking) software. Results: The obtained results revealed that all the 20 compounds show good affinity with all the proteins; significant affinity was observed between the tested compounds and Dengue transmembrane domain of NS2A protein. Conclusions: The conclusion drawn from our virtual screening and docking result reveals that the investigated compounds have a good binding affinity with most of the proteins and some of they can be used as an effective drugs target for Dengue virus.

Author Biographies

Ana Maria ZBANCIOC, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Pharmacy,
Department of Organic Chemistry

B. SATHYAMURTHY, Ramaiah College of Arts, Science and Commerce, Bangalore, India

Department of Biochemistry

Gabriela TATARINGA, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Pharmacy,
Department of Organic Chemistry


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