ADVANCING PRETERM BIRTH PREDICTION: A PROSPECTIVE MULTICENTRIC STUDY INVESTIGATING THE PREDICTIVE PERFORMANCE OF PARTOSURE, FETAL FIBRONECTIN, AND CERVICAL LENGTH
Keywords:
PRETERM BIRTH PREDICTION; PARTOSURE; PAMG-1; FETAL FIBRONECTIN; CERVICAL LENGTHAbstract
The prediction of preterm birth (PTB) is still a controversial topic, and many efforts have been made to identify the best predictive markers. The aim of this study was to prospectively assess the predictive performance of placental alpha macroglobulin-1 (PAMG-1), fetal fibronectin (fFN), and cervical length, both individually and combined, for the prediction of spontaneous preterm birth at 7 and 14 days in a cohort of pregnant patients with threatened preterm labor. Material and methods: Between October 2022 and April 2023, we performed a prospective observational study that evaluated 80 pregnant patients with singleton pregnancies, between 24 and 32 completed weeks of gestation. We qualitatively determined PAMG-1 (PartoSure test) and fFN from the vaginal fluid. Clinical data along with cervical length measurements were also retrieved. The predictive performance of the evaluated markers was determined using logistic regression and ROC analysis. Results: PartoSure obtained the best results for the prediction of PTB in the next 7 or 14 days. On the other hand, cervical length, at an established cut-off of 19 mm, had the lowest predictive performance for the evaluated outcomes. A combined algorithm that comprised PartoSure, fFN, and cervical length measurements achieved the best predictive performance for the prediction of PTB at 14 days. Conclusions: The combined algorithm is superior in terms of predictive performance for the prediction of PTB in the next 7 or 14 days. The PartoSure test could be used individually for the prediction of PTB, but clinicians need to correlate its results with other clinical findings.
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