BLOOD PRESSURE LOWERING EFFECTS OF CENTRAL TNF- BLOCKADE DEPENDS ON FUNCTIONAL LEPTIN SIGNALING

Authors

  • I. TUDORANCEA “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Ionela Lacramioara SERBAN “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • D. N. ȘERBAN “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • C. C. CATALIN “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • B. I. TAMBA “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • R. ILIESCU “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Keywords:

OBESITY, LEPTIN, TNF-α, HYPERTENSION, BAROREFLEX SENSITIVITY

Abstract

Background: Obesity is a major independent risk factor for the development and progression of arterial hypertension. Leptin-mediated sympathoexcitation is a common phenomenon in obesity. Since leptin leads to the synthesis of Tumor Necrosis Factor (TNF)-a in the central nervous system, we hypothesized that the pathological activation of the sympathetic nervous system in obesity-associated hypertension may be mediated by central leptin-related TNF-a mechanisms. Material and methods: We compared the long-term effects of TNF-a inhibition on mean arterial blood pressure, heart rate, baroreflex sensitivity and sympathetic tone in animals with a functional leptin signaling (i.e. lean Zucker rats - LZR) and in animals insensitive to leptin (i.e. obese Zucker rats - OZR). Results: central inhibition of TNF-a in normotensive LZR significantly lowered mean arterial blood pressure, decreased sympathetic activity and improved baroreflex sensitivity but not in the OZR group. Conclusions: These findings suggest that a functionally central leptin-TNF-a signaling plays a key role in mediating the central sympathetic outflow and may represent a promising approach to ameliorate the pathophysiology of obesity related-hypertension.

Author Biographies

  • I. TUDORANCEA, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Department of Morpho-functional Sciences (II). Division of Physiology
    “Sf. Spiridon” County Clinical Emergency Hospital Iasi, Romania
    Cardiology Clinic

  • Ionela Lacramioara SERBAN, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Department of Morpho-functional Sciences (II). Division of Physiology

  • D. N. ȘERBAN, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Department of Morpho-functional Sciences (II). Division of Physiology

  • C. C. CATALIN, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Advanced Research and Development Center for Experimental Medicine (CEMEX)

  • B. I. TAMBA, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Department of Morpho-functional Sciences (II). Division of Pharmacology
    Advanced Research and Development Center for Experimental Medicine (CEMEX)

  • R. ILIESCU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Department of Morpho-functional Sciences (II). Division of Pharmacology

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Additional Files

Published

2023-09-30

Issue

Vol. 127 No. 3 (2023): The Medical-Surgical Journal

Section

BASIC SCIENCES

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