THE USEFULNESS OF NEUTROPHIL-TO-LYMPHOCYTE RATIO FROM THE BRONCHOALVEOLAR LAVAGE (BNLR) IN THE ASSESSMENT OF PATIENTS WITH INTERSTITIAL LUNG DISEASE

Authors

  • Victoria Maria RUTA “Leon Daniello” Clinical Hospital of Pneumphtysiology, Cluj-Napoca, Romania
  • Rodica Ana UNGUR “Iuliu-Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
  • Nicoleta Stefania MOTOC “Leon Daniello” Clinical Hospital of Pneumphtysiology, Cluj-Napoca, Romania
  • Teodora Gabriela ALEXESCU “Iuliu-Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
  • Paraschiva POSTOLACHE “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Milena Adina MAN “Leon Daniello” Clinical Hospital of Pneumphtysiology, Cluj-Napoca, Romania

Keywords:

NEUTROPHIL-TO-LYMPHOCITE RATIO, BRONHCOALEVOLAR LAVAGE, INTER-STITIAL LUNG DISEASE

Abstract

The present study aims to evaluate the usefulness of neutrophil-to-lymphocyte ratio from the bronchoalveolar lavage (bNLR) in the assessment of local inflammatory status in patients with the stable interstitial lung disease by comparing a group of patients with IPF versus non-IPF patients. A secondary outcome was to see if we can identify values that differentiate idiopathic pulmonary fibrosis from another interstitial lung disease. Materials and methods: 42 patients with newly diagnosed ILD (24 with IPF and 18 non-IPF) were included; physical examination, high resolution CT, bronchoscopy with lavage, spirometry, DLCO and blood tests were performed in all patients. Results: We did not find any statistically significant difference between bNLR in the two groups IPF versus non IPF. bNLR were similar 2.73 + 1.14 in the non-IPF group and 2.98 ±1.72 in IPF patients, p=0.59. bNLR in patients with chronic stable newly diagnosed interstitial lung disease does not seem to bring any additional information. Conclusions: Assessment of local lung inflammation in BAL by the bNLR variable can provide minimal differential diagnostic information with higher values in IPF and HP.

Author Biographies

  • Rodica Ana UNGUR, “Iuliu-Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania

    Faculty of Medicine
    Department of Medical Specialties

  • Nicoleta Stefania MOTOC, “Leon Daniello” Clinical Hospital of Pneumphtysiology, Cluj-Napoca, Romania

    “Iuliu-Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
    Faculty of Medicine
    Department of Medical Sciences-Pulmonology

  • Teodora Gabriela ALEXESCU, “Iuliu-Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania

    Faculty of Medicine
    Department of Internal Medicine

  • Paraschiva POSTOLACHE, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Medical Specialties (II)

  • Milena Adina MAN, “Leon Daniello” Clinical Hospital of Pneumphtysiology, Cluj-Napoca, Romania

    Faculty of Medicine
    Department of Medical Sciences-Pulmonology

References

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Additional Files

Published

2023-12-21

Issue

Vol. 127 No. 4 (2023): The Medical-Surgical Journal

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INTERNAL MEDICINE - PEDIATRICS

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