ENDOPHILIN A3 IMMUNOHISTOCHEMICAL HETEROGENEITY IN PANCREATIC DUCTAL ADENOCARCINOMA
Abstract
Background and aim: Pancreatic ductal adenocarcinoma (PDAC) represents a malignant proliferation with minimally improved survival in last decades that presents systematic changes in classification framework based on new molecular and morphological data. Endophilin A3 (EndoA3), a protein involved in non-conventional endocytosis that was recently integrated in modulation of tumor cell adhesion molecule CD166/ALCAM, has not been evaluated in PDAC. Materials and methods: EndoA3 immunoreaction were qualitatively and semi-quantitatively analyzed in 87 cases of PDAC. Statically association between classic PDAC prognostic factors and Endophilin A3 immunohistochemical profile were evaluated. Results: Data analysis revealed that EndoA3 immunoprofile is associated with tumor degree of differentiation (p = 0.01). For the others microscopic prognostic factors there were no significant statistical correlations. Although not statistically significant, patients with high EndoA3 score presented the lowest survival. Conclusions: Endophilin A3 expressed in PDAC presents a cytoplasmic, diffuse or granular, tumor staining, but also a stromal staining. High EndoA3 immunoexpression appears to be associated with a negative prognosis in PDAC.
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