THE VALUE OF IMAGING INVESTIGATION IN DESIGNING OF AN EXPERIMENTAL STUDY OF BONE TISSUE DYNAMICS IN ORTHODONTIC MINI-IMPLANTS

Authors

  • R. BRAESCU Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • A. SZILAGYI “Prof. Ostin C. Mungiu” Advanced Center for Research and Development in Experimental Medicine – CEMEX
  • R.A. BAISAN “Ion Ionescu de la Brad” Iași University of Life Sciences
  • Irina-Nicoleta ZETU Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Simona-Eliza GIUSCA Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Irina-Draga CARUNTU

Abstract

Background and aim: Mini-implants play an important role in orthodontic treatment. However, the mechanism of bone remodeling associated with these orthodontic devices is not yet fully elucidated. The research focusing on the dynamics of biological changes at the implant site frequently involves experimental animal models. Our study aims to evaluate, by imaging methods, the success rate of implantation process of orthodontic mini-implants, using an original experimental model for the study of tissue biological responses present at the bone – mini-implant interface. Materials and methods: The study was conducted on adult male Sprague Dawley rats divided into 9 groups of 6 rats (G1 – G9) in which two mini-implants were surgically implanted in the right tibia. Two rats in each group also acted as controls by inserting a mini-implant in the left tibia without force. After implantation, traction forces were applied between the two mini-implants with closed NiTi helical orthodontic springs. Springs were extended at 2.2 cm, generating a force of 100 gf (G1, G4, G7); at 1.4 cm, the force generated was 75 gf (G2, G5, G8); at 1.2 cm, the force generated was 50 gf (G3, G6, G9). Animals were sacrificed at 7 days (G1, G2, G3), 21 days (G4, G5, G6), and 42 days (G7, G8, G9) from implantation. On the day of harvesting, each rat was examined radiologically by Spectral AMI HTX, Spectral Instruments. Results: The overall mini-implant success rate was 94.1%. In 5.9% of the subjects, either distal implant fracture with spring detensioning or distal implant detachment was observed. In control mini-implants, without spring, the overall success rate was 100%. Conclusions: Imaging exams are valuable tools for analyzing bone remodeling, density, and in vivo structure of bone tissue. Our study confirms the effectiveness of imaging examination in verifying the stability of the implantation stage, as a mandatory step in the subsequent evaluation of morphological changes in peri-implant bone tissue.

Author Biographies

  • R. BRAESCU, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Dental Medicine
    Department of Technology of Dental Prosthesis

  • R.A. BAISAN, “Ion Ionescu de la Brad” Iași University of Life Sciences

    Faculty of Veterinary Medicine / Cardiology and Roentgen diagnostic Unit

  • Irina-Nicoleta ZETU, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Dental Medicine
    Department of Dentoalveolar and Maxillofacial Surgery

  • Simona-Eliza GIUSCA, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Morpho-Functional Sciences (I)

  • Irina-Draga CARUNTU

    Faculty of Medicine
    Department of Morpho-Functional Sciences (I)
    Romanian Academy of Medical Sciences Iasi Branch

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Additional Files

Published

2024-06-28