SEA BUCKTHORN FRUIT OIL SUPPLEMENTATION IN ACTIVE RHEUMATOID ARTHRITIS: A FOCUS ON COMPOSITE DISEASE ACTIVITY INDICES AND EULAR RESPONSE

Authors

  • Georgeta STEFANOVICI ZUGRAVU Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Carmen PINTILESCU “Alexandru Ioan Cuza” University of Iasi, Romania
  • Carmen Marinela CUMPAT
  • S.D. MIRON Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Doina-Clementina COJOCARU Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Anca MIRON Grigore T. Popa” University of Medicine and Pharmacy Iasi

Abstract

Rheumatoid arthritis is a disabling disease whose treatment options have limitations with regard to efficacy and safety. In this respect, combination of conventional treatment with plant-derived products has attracted considerable interest in recent years. The aim of this study was to assess the impact of sea buckthorn fruit oil supplementation in patients with active rheumatoid arthritis. Materials and methods: Eighty patients, diagnosed with active rheumatoid arthritis and treated with a combination of methotrexate (15 mg/week) and diclofenac sodium (50 mg/day), were randomly (1:1) divided into control and experimental groups, the latter being supplemented with sea buckthorn fruit oil (1800 mg/day). The study lasted 12 weeks. The benefits of sea buckthorn fruit oil supplementation were evaluated by various composite disease activity indices (disease activity score in 28 joints, DAS28; simplified disease activity index, SDAI; clinical disease activity index, CDAI) and European League Against Rheumatism (EULAR) response. Results: Twelve-week supplementation with sea buckthorn fruit oil significantly (p< 0.001) reduced composite disease activity indices in comparison with baseline and control. At week 12, patients in the experimental group showed higher rates of good and moderate EULAR responses than those in the control group. Conclusions: According to our results, sea buckthorn fruit oil is a promising option for the adjunctive treatment in rheumatoid arthritis.

Author Biographies

  • Georgeta STEFANOVICI ZUGRAVU, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Pharmacy
    Department of Pharmaceutical Sciences (II)
    Faculty of Medicine
    Clinical Rehabilitation Hospital, Iasi, Romania

  • Carmen PINTILESCU, “Alexandru Ioan Cuza” University of Iasi, Romania

    Faculty of Economics and Business Administration
    Department of Accounting, Business Information Systems and Statistics

  • Carmen Marinela CUMPAT

    Faculty of Medicine
    Department of Medical Specialties (III)
    Clinical Rehabilitation Hospital, Iasi, Romania

  • S.D. MIRON, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Morpho-Functional Sciences (II)

  • Doina-Clementina COJOCARU, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Medical Specialties (III)
    Clinical Rehabilitation Hospital, Iasi, Romania

  • Anca MIRON, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Pharmacy
    Department of Pharmaceutical Sciences (II)

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Additional Files

Published

2024-06-28

Issue

Vol. 128 No. 2 (2024): The Medical-Surgical Journal

Section

PHARMACY

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