PREDICTIVE FACTORS FOR HEALTH-RELATED QUALITY OF LIFE IN TYPE 2 DIABETES PATIENTS
Abstract
Aims: Diabetes-related characteristics and associated chronic conditions are said to influence the health-related quality of life (QoL) of patients with type 2 diabetes mellitus (T2DM). This study assessed the relationships between QoL, demographic, and disease-related variables in T2DM patients without established atherosclerotic disease. Materials and methods: This post hoc analysis included outpatient data from a cross-sectional study. Descriptive and inferential statistics were used to examine patient characteristics in relation to QoL scores and identify predictive factors for physical and mental health perceptions. QoL was evaluated with the 36-item Short Form Health Survey (SF-36) questionnaire. Results: The 138 T2DM patients enrolled were 49.3% men, 57.86 ± 8.82 years old, with T2DM for 1 to 21 years, without optimal glycemic control under oral glucose-lowering drugs (median HbA1c7.8%). Mean physical and mental component summary scores (PCS, MCS) were 50.44 ± 16.22 and 47.78 ± 12.10, respectively. The lowest SF-36 scores were reported for physical functioning and vitality, and the highest for bodily pain. Women had significantly lower PCS scores compared to men (46.85 vs. 54.03, p = 0.01). The diastolic index E/e’, CHA2DS2-VASc score and diabetes duration predicted lower PCS (p ≤ 0.01), while the impact of age, glycemic control, neuropathy, diastolic dysfunction, and comorbidities on QoL was non-significant. The diastolic index E/e’, CHA2DS2-VASc score and diabetes duration predicted lower PCS (p ≤ 0.01). Conclusions: These results provide a nuanced view of what is clearly a complex set of relationships. Further longitudinal studies are necessary to ascertain the effects of these variables on the quality of life of T2DM patients.
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