CORRELATION BETWEEN BREAST ARTERIAL CALCIFICATIONS ON MAMMOGRAPHY, CHOLESTEROL LEVELS AND CARDIOVASCULAR RISK

Authors

  • Andra-Mara URSU “Sf. Spiridon” County Clinical Emergency Hospital, Iasi, Romania
  • Irina JARI Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Paloma MOISII Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • A. G. NAUM Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Corina-Veronica LUPAŞCU-URSULESCU Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Liliana GHEORGHE Grigore T. Popa” University of Medicine and Pharmacy Iasi

Keywords:

MAMMOGRAPHY, ARTERIAL CALCIFICATIONS, CARDIOVASCULAR RISK

Abstract

The objective of this study is to evaluate the correlation between arterial calcifications observed on mammograms and factors such as age, smoking status, body mass index, personal history of cardiovascular conditions, cholesterol levels (total cholesterol, LDL, HDL), and diabetes mellitus. Materials and methods: This retrospective study comprised a cohort of 1102 women, aged between 32 and 85, who underwent mammography at the “Sf. Spiridon” County Clinical Emergency Hospital Iasi from January 2018 to December 2020. Every woman underwent a routine procedure of bilateral four-view mammography. The patient’s clinical and laboratory data were retrieved from the hospital’s internal database. We selected in a random manner 115 age-matched women who did not have arterial calcifications in order to form the control group. Results: Out of the patients who received mammography, 95 cases (8.6%) showed the presence of breast arterial calcifications (BAC). As compared to control group, a significantly proportion of women with breast arterial calcifications were found to have a high body mass index (76.84%), elevated total cholesterol levels, cardiovascular diseases (21 cases, 22.10%), diabetes mellitus (15 cases, 15.78%), history of smoking (26 cases, 27.36%). Conclusions: The presence of breast arterial calcifications (BAC) on mammography is strongly linked to older age, elevated cholesterol levels, smoking, and diabetes mellitus. These patients also have a personal history of cardiovascular events, indicating a strong connection between BAC and an increased risk of cardiovascular problems. This correlation suggests that detecting BAC on mammography can serve as a marker for identifying women who are at a higher risk for experiencing cardiovascular events.

Author Biographies

  • Irina JARI, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Surgery (II)

  • Paloma MOISII, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Medical Specialties (I)

  • A. G. NAUM, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Morpho-functional Sciences (II)

  • Corina-Veronica LUPAŞCU-URSULESCU, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Surgery (II)

  • Liliana GHEORGHE, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Surgery (II)

References

1. Shanahan CM. Inflammation ushers in calcification: a cycle of damage and protection?. Circulation 2007; 116(24): 2782-2785.
2. Libby P, Hansson GK. Inflammation and immunity in diseases of the arterial tree: players and layers. Circ Res 2015; 116(2): 307-311.
3. Libby P. Interleukin-1 beta as a target for atherosclerosis therapy: biological basis of CANTOS and beyond. JACC 2017; 70(18): 2278-2289.
4. Lee SC, Phillips M, Bellinge J, Stone J, Wylie E, Schultz C. Is breast arterial calcification associated with coronary artery disease? A systematic review and meta-analysis. PloS One 2020; 15(7): e0236598.
5. Iribarren C, Chandra M, Lee C, et al. Breast arterial calcification: a novel cardiovascular risk enhancer among postmenopausal women. Circ Cardiovasc Imaging 2022; 15(3): e013526.
6. Kelly BS, Scanl ON E, Heneghan H, et al. Breast arterial calcification on screening mammography can predict significant coronary artery disease in women. Clin Imaging 2018; 49: 48-53.
7. Newallo D, Meinel FG, Schoepf UJ, et al. Mammographic detection of breast arterial calcification as an independent predictor of coronary atherosclerotic disease in a single ethnic cohort of African American women. Atherosclerosis 2015; 242 (1): 218-221.
8. Ferreira JA, Pompei LM, Fernandes CE, Azevedo LH, Peixoto S. Breast arterial calcification is a predictive factor of cardiovascular disease in Brazilian postmenopausal women. Climacteric 2009;12(5): 439-444.
9. Lee SC, Pirikahu S, Fritschi L, Boyle T, Schultz C, Wylie E, Stone J. The association between breast arterial calcification and atherosclerotic cardiovascular disease in an Australian population-based breast cancer case-control study. La radiologia medica 2023; 128(4): 426-433.
10. Yildiz S, Toprak H, Aydin S, et al. The association of breast arterial calcification and metabolic syndrome. Clin 2014; 69 (12): 841-846.
11. Pidal D, Vidal MT, Rodríguez JC, et al. Relationship between arterial vascular calcifications seen on screening mammograms and biochemical markers of endothelial injury. Eur J Radiol 2009; 69(1): 87-92.
12. Yıldız A, Seçen Ö, Yıldız C, Çiçekçi M. Relationship between breast arterial calcification and lipid profile, plasma atherogenic index, Castelli’s risk index and atherogenic coefficient in premenopausal women. IJC Metab End 2016; 11: 19-22.
13. Yi SW, Park SJ, Yi JJ, Ohrr H, Kim H. High-density lipoprotein cholesterol and all-cause mortality by sex and age: a prospective cohort study among 15.8 million adults. Int J Epidemiol 2021; 50: 902-913.
14. Vogel B, Acevedo M, Appelman Y, et al. The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030. Lancet 2021; 397(10292): 2385-2438.
15. Martinho M. et al. Women more likely to die after heart attack than men. In: Proceedings in Heart Failure, Congress of European Society of Cardiology. Topics Heart Failure 22 May 2023 Prague, Czechia.
16. Hosseini N, Kaier T. Gender Disparity in Cardiovascular Disease in the Era of Precision Medicine. JACC Case Rep 2023 / doi.10.1016/j.jaccas.2023.101985.
17. Hendriks EJ, de Jong PA, van der Graaf Y, Mali WP, van der Schouw YT, Beulens JW. Breast arterial calcifications: a systematic review and meta-analysis of their determinants and their association with cardiovascular events. Atherosclerosis 2015; 239: 11-20.
18. Iribarren C, Go AS, Tolstykh I, Sidney S, Johnston SC, Spring DB. Breast vascular calcification and risk of coronary heart disease, stroke, and heart failure. J Womens Health 2004; 13: 381-389
19. Cetin M, Cetin R, Tamer N. Prevalence of breast arterial calcification in hypertensive patients. Clin Radiol 2004; 59: 92-95.
20. Çetin M, Çetin R, Tamer N, Kelekçi S. Breast arterial calcifications associated with diabetes and hypertension. J Diabetes Complications 2004; 18(6): 363-366.
21. Ilica AT, Aydogan U, Guvenc I, et al. Risk factors associated with breast arterial calcifications. Acta Radiol 2011; 52(7): 702-705.
22. Osman M, Regner S, Osman K, et al. Association between breast arterial calcification on mammog-raphy and coronary artery disease: a systematic review and meta-analysis. J Womens Health 2022; 31(12): 1719-1726.
23. Amann K. Media calcification and intima calcification are distinct entities in chronic kidney disease. Clin J Am Soc Nephrol 2008; 3 (6): 1599-1605.

Additional Files

Published

2024-09-18