STATIC AND WHOLE-BODY IMAGES VS. SPECT: TOGETHER OR SEPARATE FOR AN ACCURATE DETECTION OF TRANSTHYRETIN CARDIAC AMYLOIDOSIS

Authors

  • T. M. IONESCU Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Irena GRIEROSU Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Manuela CIOCOIU Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • W. JALLOUL Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Cati STOLNICEANU Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Roxana IACOB Regional Institute of Oncology Iasi, Romania
  • R. V. LUPUȘORU Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • R. SASCAU Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Cipriana ȘTEFĂNESCU Grigore T. Popa” University of Medicine and Pharmacy Iasi

Abstract

Transthyretin cardiac amyloidosis (ATTR-CA) is a protein deposition disease that represents a challenge to be diagnosed by the practicing physician. As the gold standard method is not widely available correlations between biomarkers, electrocardiography, echocardiography, bone scintigraphy and free light chain dosage has proven to be a reliable alternative. Bone scintigraphy represents the corner stone for ATTR-CA detection; however, some patients cannot undergo all the required images for an easy and accurate diagnosis. Therefore, the aim of this study is to determine the bare minimum images that can be performed for an accurate diagnosis. Materials and methods: 80 patients that met the inclusion criteria were evaluated throw bone scintigraphy. Acquired images included: whole body bone scan (early and delayed), static followed by Single Photon Emission Computed Tomography (SPECT), if possible, centered on the thorax. Images were interpreted by visual scoring and semiquantitative methods. Results: 20 patients were diagnosed with ATTR cardiac amyloidosis by visual scoring, however not all of them underwent all the necessary images. Semiquantitative methods results were above the established threshold and therefore sustained the visual score. Nevertheless, ratio results differed between static and SPECT images. Conclusions: Ideally all type of images should be acquired for this type of patients, however, we determined that a minimum of whole-body ± static centered on the thorax images interpreted throw visual scoring and semiquantitative analysis can be enough if SPECT is not possible for a reliable diagnosis.

Author Biographies

  • Irena GRIEROSU, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    “Sf. Spiridon” County Clinical Emergency Hospital Iasi, Romania

  • Cati STOLNICEANU, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    “Sf. Spiridon” County Clinical Emergency Hospital Iasi, Romania

  • R. SASCAU, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    “Prof. Dr. George I.M. Georgescu” Cardiovascular Diseases Institute Iasi, Romania

  • Cipriana ȘTEFĂNESCU, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    “Sf. Spiridon” County Clinical Emergency Hospital Iasi, Romania

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Additional Files

Published

2024-09-18