IMPACT OF TREATMENT ON QUALITY OF LIFE IN PATIENTS DIAGNOSED WITH POTENTIALLY MALIGNANT ORAL DISEASES

Authors

  • Bianca-Andreea ONOFREI Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Cristina POPA Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Elena-Raluca BACIU Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • V. V. COSTAN Grigore T. Popa” University of Medicine and Pharmacy Iasi

Abstract

This study aimed to investigate the impact of treatment on the quality of life (QoL) in patients diagnosed and treated for potentially malignant oral diseases (OPMDs) such as leukoplakia, oral lichen planus, and actinic cheilitis. OPMDs are chronic diseases with a significant risk of cancerous transformation, affecting 1% to 5% of the global population. Symptoms like pain, burning sensation, trismus, and altered taste adversely affect patients’ QoL, compounded by delays in diagnosis. Materials and methods: This cross-sectional study, conducted from June 2023 to June 2024, involved 30 patients from the “Sf. Spiridon” Emergency Clinical Hospital in Iasi, Romania. Participants were assessed using a disease-specific QoL questionnaire, which included 20 questions across four subscales: difficulty with diagnosis, physical and functional limitations, psychological and social well-being, and the effect of treatment on daily life. Results: Participants consisted of 16 males (53.3%) and 14 females (46.7%), aged between 42 and 75 years, with an average age of 64.61±13.69 years. Patients with oral lichen planus and leukoplakia had a statistically significantly lower quality of life compared to patients with actinic cheilitis (p = 0.038). Conclusions: The three groups indicated a varied impact of the diseases and treatments on different aspects of life. Implementing disease-specific QoL assessment tools can aid in better understanding and addressing the special needs of OPMD patients, ultimately improving treatment outcomes and patient care.

Author Biographies

  • Bianca-Andreea ONOFREI, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Ph.D. Student

  • Cristina POPA, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Dental Medicine
    Department of Surgery

  • Elena-Raluca BACIU, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Dental Medicine
    Department of Implantology, Removable Dentures, Dental Technology

  • V. V. COSTAN, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Dental Medicine
    Department of Surgery

References

1. Kumar K, Khandpur M, Khandpur S, Mehrotra D, Chandra Tiwari S, Kumar S. Quality of life among Oral Potentially Malignant Disorder (OPMD) patients: A prospective study. J Oral Biol Craniofac Re 2021; 11(1): 88-91.
2. Abati S, Bramati C, Bondi S, Lissoni A, Trimarchi M. Oral Cancer and Precancer: A Narrative Review on the Relevance of Early Diagnosis. Int J Environ Res Public Health 2020; 17(24): 9160.
3. Gondivkar SM, Bhowate RR, Gadbail AR, Sarode SC, Patil S. Quality of life and oral potentially malignant disorders: Critical appraisal and prospects. World J Clin Oncol 2018; 9(4): 56-59.
4. Mello FW, Miguel AFP, Dutra KL, et al. Prevalence of oral potentially malignant disorders: A sys-tematic review and meta-analysis. J Oral Pathol Med 2018; 47(7): 633-640.
5. van der Waal I. Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management. Oral Oncol 2009; 45(4-5): 317-323.
6. George A, Sreenivasan BS, Sunil S, et al. Potentially Malignant Disorders of Oral Cavity. Oral and Maxillofacial Pathology Journal 2011; 2(1): 95-100.
7. Mortazavi H, Baharvand M, Mehdipour M. Oral potentially malignant disorders: an overview of more than 20 entities. J Dent Res Dent Clin Dent Prospects 2014; 8(1): 6-14.
8. Tadakamadla J, Kumar S, Lalloo R, Gandhi Babu DB, Johnson NW. Impact of oral potentially ma-lignant disorders on quality of life. J Oral Pathol Med 2018; 47(1): 60-65.
9. Gondivkar SM, Bhowate RR, Gadbail AR, Sarode SC, Patil S. Quality of life and oral potentially malignant disorders: Critical appraisal and prospects. World J Clin Oncol 2018; 9(4): 56-59.
10. Gondivkar SM, Gadbail AR, Gondivkar RS, Sarode SC, Sarode GS, Patil S. Impact of oral potentially malignant disorders on quality of life: a systematic review. Future Oncol 2018; 14(10): 995-1010.
11. Tabolli S, Bergamo F, Alessandroni L, Di Pietro C, Sampogna F, Abeni D. Quality of life and psy-chological problems of patients with oral mucosal disease in dermatological practice. Dermatology 2009; 218(4): 314-320.
12. McGrath C, Hegarty AM, Hodgson TA, Porter SR. Patient-centered outcome measures for oral mu-cosal disease are sensitive to treatment. Int J Oral Maxillofac Surg 2003; 32(3): 334-336.
13. Ni Riordain R, Meaney S, McCreary C. A patient-centered approach to developing a quality-of-life questionnaire for chronic oral mucosal diseases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 111(5): 578-586.
14. Tadakamadla J, Kumar S, Lalloo R, Johnson NW. Development and validation of a quality-of-life questionnaire for patients with oral potentially malignant disorders. Oral Surg Oral Med Oral Pathol Oral Radiol 2017; 123(3): 338-349.
15. Kapur N, Singla N, Kudva A, John ER. Evaluation of quality of life in patients surgically treated for potentially malignant oral lesions. Indian J Cancer 2021; 58(3): 371-377.
16. Ashshi RA, Stanbouly D, Maisano PG, et al. Quality of life in patients with oral potentially malignant disorders: oral lichen planus and oral epithelial dysplasia. Oral Surg Oral Med Oral Pathol Oral Radiol 2023; 135(3): 363-371.
17. Karbach J, Al-Nawas B, Moergel M, Daubländer M. Oral health-related quality of life of patients with oral lichen planus, oral leukoplakia, or oral squamous cell carcinoma. J Oral Maxillofac Surg 2014; 72(8): 1517-1522.
18. Rajan B, Ahmed J, Shenoy N, Denny C, Ongole R, Binnal A. Assessment of quality of life in patients with chronic oral mucosal diseases: a questionnaire-based study. Perm J 2014; 18(1): e123-e127.
19. Min Ang X, Chi Khang Au P, Kwok K, et al. Quality of life in patients with oral leukoplakia. J Oral Pathol Med 2019; 48(7): 574-580.

Additional Files

Published

2024-09-18

Issue

Vol. 128 No. 3 (2024): The Medical-Surgical Journal

Section

DENTAL MEDICINE

License

COPYRIGHT 
Once an article is accepted for publication, MSJ requests a transfer of copyrights for published articles.

COPYRIGHT TRANSFER FORM FOR 

REVISTA MEDICO-CHIRURGICALĂ A SOCIETĂȚII DE MEDICI ȘI NATURALIȘTI DIN IAȘI /

THE MEDICAL-SURGICAL JOURNAL OF THE SOCIETY OF PHYSICIANS AND NATURALISTS FROM IASI

We, the undersigned authors of the manuscript entitled

_____________________________________________________________________________________

_____________________________________________________________________________________

warrant that this manuscript, which is submitted for publication in the REVISTA MEDICO-CHIRURGICALĂ, has not been published and it is not under consideration for publication in another journal.

  1. we give the consent for publication in the REVISTA MEDICO-CHIRURGICALĂ, in printed and electronic format and we transfer unconditioned and complete the copyright of this manuscript to the REVISTA MEDICO-CHIRURGICALĂ, in the event of its acceptance.
  2. the manuscript does not break the intellectual property rights of any other person.
  3. we have read the submitted version of the manuscript and we are fully responsible for the content.

Names and signatures of authors / copyright owners (the following sequence is the authorship of the article):

  1. ______________________________/_________________________
  2. ______________________________/_________________________
  3. ______________________________/_________________________

N.B.  All the authors must sign this form