RETROSPECTIVE STUDY ON THYROID FUNCTION MODIFICATIONS IN PATIENTS DIAGNOSED WITH POLYCYSTIC OVARY SYNDROME

Authors

  • Raluca Anamaria MOGOS ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Ingrid-Andrada VASILACHE ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • A. CARAULEANU “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania
  • Demetra SOCOLOV ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Simona-Juliette MOGOS ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Cristina PREDA ‟Grigore Popa” University of Medicine and Pharmacy Iași

Abstract

Polycystic ovary syndrome (PCOS) is a complex endocrine condition, and its association with thyroid dysfunction is variably reported in the literature. The aim of the study was to retrospectively evaluate the degree of association between PCOS and thyroid impairment in a cohort of 269 patients. Materials and methods: The study had a retrospective observational design. The data were analyzed descriptively and using a multivariate logistic regression model to analyze the association between thyroid status and the type of thyroid disorder with each PCOS phenotype individually. The results were reported as relative risk ratios (RRR) and 95% confidence intervals (CI). Results: The presence of phenotype A in the context of advanced age increased the risk of developing hyperthyroidism by 9% (RRR: 1.06, 95% CI: 1.01-1.12, p=0.019), while in the context of a normal or low BMI, it decreased the risk of developing hyperthyroidism by 93% (RRR: 0.07, 95% CI: 0.08-0.68, p=0.021). Phenotype B in the context of a normal or low BMI increased the risk of developing hyperthyroidism by over 15 times (RRR: 15.86, 95% CI: 1.23-30.3, p=0.03). Conclusions: Early identification of thyroid abnormalities in patients with PCOS is warranted and requires an individualized therapeutic approach.

Author Biographies

  • Raluca Anamaria MOGOS, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    Department of Mother and Child Medicine

  • Ingrid-Andrada VASILACHE, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    Department of Mother and Child Medicine

  • A. CARAULEANU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania

    Faculty of Medicine
    Department of Mother and Child Medicine

  • Demetra SOCOLOV, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    Department of Mother and Child Medicine

  • Simona-Juliette MOGOS, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    Department of Medical Specialties (II)

  • Cristina PREDA, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    Department of Medical Specialties (II)

References

1. Strikić Đula I, Pleić N, Babić Leko M, et al. Epidemiology of hypothyroidism, hyperthyroidism and positive thyroid antibodies in the Croatian population. Biology 2022; 11(3): 394.

2. Stoll K. Disparities in thyroid screening and medication use in Quebec, Canada. Health Equity 2019; 3(1): 328-335.

3. Abdulla J, Abubaker F, Saber F. Thyroid dysfunction among adults in Bahrain: A hospital-based study. Neuro endocrinology letters 2020; 41(1): 1-9.

4. Song R-h, Wang B, Yao Q-m, Li Q, Jia X, Zhang J-a. The impact of obesity on thyroid autoimmunity and dysfunction: a systematic review and meta-analysis. Frontiers in immunology. 2019; 10: 443404.

5. Dhillon-Smith RK, Tobias A, Smith PP, et al. The prevalence of thyroid dysfunction and autoimmunity in women with history of miscarriage or subfertility. The Journal of Clinical Endocrinology & Metabolism 2020; 105(8): 2667-2677.

6. Shekhar S, Hall JE, Klubo-Gwiezdzinska J. The hypothalamic–pituitary–thyroid axis and sleep. Current opinion in endocrine and metabolic research 2021; 17: 8-14.

7. de Medeiros SF, de Medeiros MAS, Ormond CM, Barbosa JS, Yamamoto MMW. Subclinical hypothyroidism impact on the characteristics of patients with polycystic ovary syndrome. A meta-analysis of observational studies 2018; 105-115.

8. Quintino-Moro A, Zantut-Wittmann DE, Tambascia M, Machado HdC, Fernandes A. High prevalence of infertility among women with Graves’ disease and Hashimoto’s thyroiditis. International Journal of Endocrinology 2014; 2014(1): 982705.

9. Silva JF, Ocarino NM, Serakides R. Thyroid hormones and female reproduction. Biology of repro-duction 2018; 99(5): 907-921.

10. Sonigo C, Bouilly J, Carré N, Tolle V, Caraty A, Tello J, et al. Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration. The Journal of Clinical Investigation 2012; 122(10): 3791-3795.

11. Donato Jr J, Frazão R. Interactions between prolactin and kisspeptin to control reproduction. Archives of Endocrinology and Metabolism 2016; 60(06): 587-595.

12. Petrine J, Franci CR, Del Bianco-Borges B. Leptin actions through the nitrergic system to modulate the hypothalamic expression of the kiss1 mRNA in the female rat. Brain Research 2020; 1728: 146574.

13. Selva DM, Hammond GL. Thyroid hormones act indirectly to increase sex hormone-binding globulin production by liver via hepatocyte nuclear factor-4alpha. J Mol Endocrinol 2009; 43(1): 19-27.

14. Aghajanova L, Stavreus-Evers A, Lindeberg M, Landgren B-M, Sparre LS, Hovatta O. Thyroid-stimulating hormone receptor and thyroid hormone receptors are involved in human endometrial physiology. Fertility and sterility 2011; 95(1): 230-237.

15. Brown EDL, Obeng-Gyasi B, Hall JE, Shekhar S. The Thyroid Hormone Axis and Female Repro-duction. Int J Mol Sci 2023; 24(12): 9815.

16. Weetman A. An update on the pathogenesis of Hashimoto’s thyroiditis. Journal of Endocrinological Investigation. 2021; 44(5): 883-890.

17. Hoeger KM, Dokras A, Piltonen T. Update on PCOS: Consequences, Challenges, and Guiding Treatment. J Clin Endocrinol Metab 2021; 106(3): e1071-e1083.

18. Glintborg D, Rubin KH, Nybo M, Abrahamsen B, Andersen M. Increased risk of thyroid disease in Danish women with polycystic ovary syndrome: a cohort study. Endocrine connections 2019; 8(10): 1405-1415.

19. Raj D, Pooja F, Chhabria P, et al. Frequency of subclinical hypothyroidism in women with polycystic ovary syndrome. Cureus 2021; 13(9): e17722.

20. Saeed WM, Alsehli F. Thyroid hormones and cardiometabolic risk factors in Saudi women with polycystic ovary syndrome: A cross-sectional study. International Journal of Women’s Health 2023; 15: 1197-1203.

21. van der Ham K, Stekelenburg KJ, Louwers YV, et al. The prevalence of thyroid dysfunction and hyperprolactinemia in women with PCOS. Frontiers in Endocrinology 2023; 14: 1245106.

22. Fauser BC, Tarlatzis BC, Rebar RW, et al. Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril 2012; 97(1): 28-38. e25.

23. Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil Steril 2016; 106(1): 6-15.

24. Bozdag G, Mumusoglu S, Zengin D, Karabulut E, Yildiz BO. The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod 2016; 31(12): 2841-2855.

25. Pavaleanu I, Gafitanu D, Popovici D, Duceac LD, Pavaleanu M. Treatment of metabolic alterations in Polycystic Ovary Syndrome. Med Surg J - Rev Med Chir Soc Med Nat Iasi 2016; 120(2): 258-263.

26. Damian L, Ghiciuc CM, Ungureanu M-C, Patacchioli FR, Lupușoru CE. Reduction of Subjective Stress Perception In Female Patients With Autoimmune Hypothyroidism After Restoring Euthyroid Status With Levothyroxine Treatment. Med Surg J - Rev Med Chir Soc Med Nat Iasi 2017; 121(3): 486-492.

27. Moran C, Arriaga M, Rodriguez G, Moran S. Obesity Differentially Affects Phenotypes of Polycystic Ovary Syndrome. International Journal of Endocrinology 2012; 2012(1): 317241.

28. Bhandari M, Kosta S, Bhandari M, Reddy M, Mathur W, Gupta M. Effects of Bariatric Surgery on People with Obesity and Polycystic Ovary Syndrome: A Large Single Center Study from India. Obes Surg 2022; 32(10): 3305-3312.

29. Shi D, Du J, Kang H, Feng L, Liu F. The effect of subclinical hypothyroidism on hormonal and metabolic profiles and ovarian morphology in patients with polycystic ovary syndrome: a cross-sectional study. Gynecol Endocrinol. 2024; 40(1): 2358219.

30. Bonakdaran S, Milani N, Khorasani ZM, Hosseinzadeh M, Kabiri M. Is There a Relation between Hypothyroidism and Polycystic Ovary Syndrome and its Metabolic Components? Curr Diabetes Rev 2023; 19(2): e260422204034.

Additional Files

Published

2024-12-23

Issue

Section

INTERNAL MEDICINE - PEDIATRICS