THE PREDICTIVE VALUE OF RED BLOOD CELL DISTRIBUTION WIDTH-COEFFICIENT OF VARIATION IN PREGNANT PATIENTS WITH TREATED THROMBOPHILIA WHO DELIVERED VIA CESAREAN SECTION AT TERM

Authors

  • Catalina FILIP ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Roxana COVALI ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Ingrid Andrada VASILACHE ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • A. CARAULEANJ ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Mona AKAD ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Ioana Sadyie SCRIPCARIU ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • T. BUTUREANU ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Gabriela DUMACHITA-SARGU ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Diana LACATUSU ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • L. V. BOICULESE ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Alina MELINTE POPESCU “Ștefan cel Mare” University, Faculty of Medicine and Biological Sciences, Suceava, Romania
  • R. SOCOLOV ‟Grigore Popa” University of Medicine and Pharmacy Iași

Abstract

RDW-CV has predictive value in many early-pregnancy-related conditions. Research question: Can RDW-CV be utilized predictively in pregnant patients at term with thrombophilia? Materials and methods: We compared RDW-CV values, antepartum and postpartum, according to postpartum uterine involution, maternal features, and fetal outcomes in 79 pregnant patients with treated thrombophilia, who formed the study group, and in another 80 patients of a similar age and parity, who formed the control group. Every patient received a sonogram during the first 1–2 days after the cesarean section, and their uterine evaluation was interpreted using the PUUS (Postpartum Uterine Ultrasonographic Scale). Results: Our group of PUUS ≥ 1 pregnant and postpartum patients with treated thrombophilia was the only group with an RDW-CV value over 14. An RDW-CV of 14.5 was the highest value in the Rh-negative group of pregnant patients with treated thrombophilia. An RDW-CV of 14.48 was the highest level in the Rh-negative postpartum patients with treated thrombophilia. (4) Conclusions: An RDW-CV of ≥14 might predict uterine hematometra (PUUS ≥ 1). The RDW-CV values were higher in the Rh-negative patients. 

Author Biographies

  • Catalina FILIP, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine

  • Roxana COVALI, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Bioengineering
    “Cuza-Vodă” Clinical Hospital of Obstetrics and Gynecology Iasi, Romania

  • Ingrid Andrada VASILACHE, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    “Elena-Doamna” Clinical Hospital of Obstetrics and Gynecology Iasi, Romania

  • A. CARAULEANJ, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    “Elena-Doamna” Clinical Hospital of Obstetrics and Gynecology Iasi, Romania

  • Mona AKAD, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    “Cuza-Vodă” Clinical Hospital of Obstetrics and Gynecology Iasi, Romania

  • Ioana Sadyie SCRIPCARIU, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    “Elena-Doamna” Clinical Hospital of Obstetrics and Gynecology Iasi, Romania

  • T. BUTUREANU, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    “Cuza-Vodă” Clinical Hospital of Obstetrics and Gynecology Iasi, Romania

  • Gabriela DUMACHITA-SARGU, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    “Cuza-Vodă” Clinical Hospital of Obstetrics and Gynecology Iasi, Romania

  • Diana LACATUSU, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Pharmacy

  • L. V. BOICULESE, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine

  • R. SOCOLOV, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    “Cuza-Vodă” Clinical Hospital of Obstetrics and Gynecology Iasi, Romania

References

1. Alageel AA, Alhaizan MA, Neyazi SM, Al-Hakeem MM, Ali Khan I. Molecular Screening of the Thrombophilic Variants Performed at G-141 Laboratory among Saudi Infertile Women. Appl Sci 2023; 13: 13028 / doi:10.3390/app132413028.

2. Ashorobi D, Ameer MA, Fernandez R. Thrombosis. In StatPearls [Internet]; StatPearls Publishing: Treasure Island, FL, USA, 2019.

3. Sim JH, Cho HS, Jang DM, et al. Effect of intraoperative blood transfusion on inflammatory response in parturients with placenta previa undergoing cesarean section: A prospective observational study. Heliyon 2023; 9: e13375 / doi:10.1016/j.heliyon.2023.e13375.

4. Socolov R, Akad M, Pavaleanu M, et al. The Rare Case of a COVID-19 Pregnant Patient with Quadruplets and Postpartum Severe Pneumonia. Case Report and Review of the Literature. Medicina 2021; 57: 1186 / doi:10.3390/medicina57111186.

5. Covali R, Socolov D, Socolov R. Coagulation tests and blood glucose before vaginal delivery in healthy teenage pregnant women compared with healthy adult pregnant women. Medicine 2019; 98: e14360 / doi:10.1097/MD.0000000000014360.

6. Febra C, Spinu V, Ferreira F, et al. Predictive Value for Increased Red Blood Cell Distribution Width in Unprovoked Acute Venous Thromboembolism at the Emergency Department. Clin. Appl Thromb Hemost 2023; 29: 10760296231193397 / doi:10.1177/10760296231193397.

7. Filip C, Covali R, Socolov D, et al. The Postpartum Uterine Ultrasonographic Scale in Assessment of Uterine Involution after Cesarean Section in Treated Thrombophilia Pregnant Patients at Term. J Clin Lab Anal 2022; 36: e24645 / doi:10.1002/jcla.24645.

8. Covali R, Socolov D, Carauleanu A, et al. The Importance of the Novel Postpartum Uterine Ultrasonographic Scale in Numerical Assessments of Uterine Involution Regarding Perinatal Maternal and Fetal Outcomes. Diagnostics (Basel) 2021; 11(9): 1731 / doi: 10.3390/ diagnostics1109 1731.

9. Lippi G, Henry BM, Mattiuzzi C. Red blood cell distribution width (RDW) reflects disease severity in patients with carbon monoxide poisoning: Systematic literature review and meta-analysis. Scand J Clin Lab Investig 2024; 84: 79-83 / doi:10.1080/00365513.2024.2332998.

10. Vega-Sánchez R, Tolentino-Dolores MC, Cerezo-Rodríguez B, et al. Erythropoiesis and Red Cell Indices Undergo Adjustments during Pregnancy in Response to Maternal Body Size but not Inflammation. Nutrients 2020; 12: 975 / doi:10.3390/nu12040975.

11. Sokol Karadjole V, D’Amato A, Milošević M, et al. Impact of Thrombophilic Polymorphisms in Antenatal Women on Perinatal Health: A Single-Center Prospective Study. J Pers Med 2024; 14: 433 / doi:10.3390/jpm14040433.

Additional Files

Published

2024-12-23