RELATIONSHIPS BETWEEN CLINICAL MANIFESTATIONS AND HISTOPATHOLOGICAL FEATURES IN ENDOMETRIOSIS: IMPLICATIONS FOR PRECISION DIAGNOSIS AND TREATMENT

Authors

  • B. TOMA ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Bianza CHIFU ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Demetra SOCOLOV ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • M. ONOFRIESCU ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Sorana ANTON ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • B. CIUNTU ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • E. ANTON ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Cristina DIMITRIU “Elena-Doamna” Clinical Hospital of Obstetrics and Gynecology Iasi, Romania
  • Mihaela CORLADE-ANDREI ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Mihaela TIRNOVANU ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Andreea PRUTEANU “Elena-Doamna” Clinical Hospital of Obstetrics and Gynecology Iasi, Romania
  • R. SOCOLOV ‟Grigore Popa” University of Medicine and Pharmacy Iași

Abstract

Endometriosis is a chronic inflammatory disease affecting reproductive-age women, often associated with pain and infertility. Aim: This study aims seeks to investigate the relationships between clinical and paraclinical presentations, and histopathological features in endometriosis, with the objective of improving diagnostic accuracy and guiding personalized treatment strategies. Materials and methods: A prospective study was carried out involving 40 patients evaluated at “Cuza-Vodă” and “Elena-Doamna” Obstetrics and Gynecology Clinical Hospitals, Iasi, between September 2019 to August 2024, of whom 40 met the inclusion criteria. Key clinical data and biomarker levels, including CA-125, neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte ratios (PLR) and systemic immune inflammation index (SII) were analyzed for correlations with histopathological findings, as well as with rASRM staging and the EFI index. Results: Compared to the control group, the association of elevated CA-125 levels with systemic inflammatory markers (NLR, PLR, SII) highlights the chronic inflammatory process characteristic of this pathology. In terms of systemic inflammatory markers, the rASRM classification identifies lower values in stage IV compared to stage III, while the EFI classification does not reveal any significant changes. Conclusions: The study highlights the importance of correlating clinical and histopathological data in endometriosis for a more nuanced staging and personalized treatment approach. The association of CA-125, systemic inflammatory markers, and rASRM staging may provide the foundation for the identification of novel non-invasive biomarkers, as well as potential prognostic factors for endometriosis.

Author Biographies

  • B. TOMA, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    Department of Morpho-Functional Sciences (I)
    “Cuza-Vodă” Clinical Hospital of Obstetrics and Gynecology Iasi, Romania

  • Bianza CHIFU, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    Department of Morpho-Functional Sciences (I)

  • Demetra SOCOLOV, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    Department of Mother and Child Medicine
    “Cuza-Vodă” Clinical Hospital of Obstetrics and Gynecology Iasi, Romania

  • M. ONOFRIESCU, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    Department of Mother and Child Medicine
    “Cuza-Vodă” Clinical Hospital of Obstetrics and Gynecology Iasi, Romania

  • Sorana ANTON, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    Department of Mother and Child Medicine
     “Cuza-Vodă” Clinical Hospital of Obstetrics and Gynecology Iasi, Romania

  • B. CIUNTU, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    Department of Surgery (I)
    “Sf. Spiridon” County Clinical Emergency Hospital Iasi

  • E. ANTON, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    Department of Mother and Child Medicine
    “Elena-Doamna” Clinical Hospital of Obstetrics and Gynecology Iasi, Romania

  • Cristina DIMITRIU, “Elena-Doamna” Clinical Hospital of Obstetrics and Gynecology Iasi, Romania

    Sf. Spiridon” County Clinical Emergency Hospital Iasi

  • Mihaela CORLADE-ANDREI, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    Department of Surgery (II)
    “Sf. Spiridon” County Clinical Emergency Hospital Iasi

  • Mihaela TIRNOVANU, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    Department of Mother and Child Medicine
    “Cuza-Vodă” Clinical Hospital of Obstetrics and Gynecology Iasi, Romania 

  • R. SOCOLOV, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    Department of Mother and Child Medicine
    “Elena-Doamna” Clinical Hospital of Obstetrics and Gynecology Iasi, Romania

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Additional Files

Published

2024-12-23