EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF NITRO-L-ARGININE METHYL ESTER DERIVATIVES WITH THIAZOLIDIN-4-ONE SCAFFOLD

Authors

  • Andreea-Teodora IACOB ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Florentina Geanina LUPASCU ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Bianca-Ștefania PROFIRE ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Maria APOTROSOAEI ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Ioana-Mirela VASINCU ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Oana-Maria IONESCU ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • D. LUPASCU ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Roxana-Georgiana TAUSER ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Lenuta PROFIRE ‟Grigore Popa” University of Medicine and Pharmacy Iași

Abstract

This paper is focused on the evaluation of the anti-inflammatory potential of some novel nitro-L-arginine methyl ester derivatives with thiazolidin-4-one structure, synthesized by our research group. Materials and methods: The evaluation of the anti-inflammatory potential was performed using in vitro assays: human red blood cell membrane stabilization (HRBC) and inhibiting bovine serum albumin denaturation (BSA) assays. Results: The obtained results showed that both stability of the erythrocyte membrane and inhibition of bovine serum albumin (BSA) denaturation, as parameters of anti-inflammatory effect evaluation, depend on the structure and concentration of the tested compounds. The most active derivatives were the compounds in which the aromatic ring from 2-position of thiazolidine-4-one scaffold is unsubstituted (2a) and halogen-substituted (with 4-chloro – 2c, and 4-bromo– 2e). Conclusions: The most favorable influence was obtained by the aromatic substitution with chloro and bromo in para position, the corresponding derivatives being the most active derivatives compared to diclofenac, used as anti-inflammatory standard. 

Author Biographies

  • Andreea-Teodora IACOB, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Pharmacy,
    Department of Pharmaceutical and Therapeutical Chemistry 

  • Florentina Geanina LUPASCU, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Pharmacy,
    Department of Pharmaceutical and Therapeutical Chemistry

  • Bianca-Ștefania PROFIRE, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine,
    Department of Medical Specialties (I)

  • Maria APOTROSOAEI, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Pharmacy,
    Department of Pharmaceutical and Therapeutical Chemistry

  • Ioana-Mirela VASINCU, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Pharmacy,
    Department of Pharmaceutical and Therapeutical Chemistry 

  • Oana-Maria IONESCU, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Pharmacy,
    Department of Pharmaceutical and Therapeutical Chemistry 

  • D. LUPASCU, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Pharmacy,
    Department of Pharmaceutical and Therapeutical Chemistry 

  • Roxana-Georgiana TAUSER, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Pharmacy,
    Department of Pharmaceutical and Therapeutical Chemistry 

  • Lenuta PROFIRE, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Pharmacy,
    Department of Pharmaceutical and Therapeutical Chemistry 

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Additional Files

Published

2024-12-23