A RETROSPECTIVE INVESTIGATION ON THE INCIDENCE, CLINICAL CHARACTERISTICS, AND OUTCOMES OF PNEUMOTHORAX IN HOSPITALIZED COVID-19 PATIENTS IN NORTH-EAST OF ROMANIA
DOI:
https://doi.org/10.22551/8k82sn68Abstract
The COVID-19 clinic ranges from asymptomatic to critical and fatal disease. Pneumothorax and pneumomediastinum are rare complications of COVID-19 infection but can occur at any time during the disease. The aim of this retrospective study was to analyze the impact of acute respiratory complications on patients diagnosed with SARS-CoV-2 infection. Materials and methods: 177 patients with COVID-19 were recruited to analyze the correlation between pneumothorax and demographics and general data of the patients. Results: In our study, pneumothorax or pneumomediastinum was much more frequent among younger, smoking individuals from urban environments. Moreover, the pneumothorax group had statistically significantly higher white blood cells and erythrocyte sedimentation rate values than the control group. The duration of hospitalization in patients who developed pneumothorax was similar to those who did not develop this complication. Conclusions: Patients experiencing this consequence had a significantly higher mortality rate compared to those in control groups. Although the precise origins of this complication remain unclear, individuals with preexisting pulmonary dysfunction appear to experience it more frequently.
References
1. Azeem A, Noor Butt D, Carrig M, Krajicek B, Destache C, Velagapudi M. Incidence and Prognosis of Pneumothorax and Pneumomediastinum in Hospitalized Patients With COVID-19 Pneumonia. WMJ 2023; 122(5): 337-341.
2. Fujita K, Iwata T, Kanai O, et al. Clinical features of pneumothorax associated with COVID-19: A retrospective analysis of two centers. Respir Investig 2024; 62(1): 137-141 / doi: 10.1016/j.resinv.2023.12.001.
3. Chopra A, Al-Tarbsheh AH, Shah NJ, et al. Pneumothorax in critically ill patients with COVID-19 infection: Incidence, clinical characteristics and outcomes in a case control multicenter study. Respir Med. 2021 Aug; 184: 106464 / doi: 10.1016/j.rmed.2021.106464.
4. Sun R, Liu H, Wang X. Mediastinal Emphysema, Giant Bulla, and Pneumothorax Developed during the Course of COVID-19 Pneumonia. Korean J Radiol 2020; 21(5): 541-544 / doi: 10.3348/kjr.2020. 0180.
5. X.-H. Wang, et al., High incidence and mortality of pneumothorax in critically ill patients with COVID-19. Heart Lung 2021; 50(1): 37-43 / doi: 10.1016/j.hrtlng.2020.10.002.
6. McGuinness G, Zhan C, Rosenberg N, et al. Increased Incidence of Barotrauma in Patients with COVID-19 on Invasive Mechanical Ventilation. Radiology 2020; 297(2): E252-E262 / doi: 10.1148/radiol.2020202352.
7. Kawachi J, Koyama H, Aida Y, Kamio T, Yamagami H, Nishiguchi S. Spontaneous pneumothorax with coronavirus disease 2019 in non-ventilated patients: A single-center retrospective case series. Ann Med Surg (Lond) 2021; 72: 103134 / doi: 10.1016/j.amsu. 2021.103134.
8. Martinelli AW, Ingle T, Newman J, et al. COVID-19 and pneumothorax: a multicenter retrospective case series Eur Respir J 2020; 56(5): 2002697 / doi: 10.1183/ 13993003.02697-2020.
9. Ershadi R, Rafieian S, Salehi M, et al. COVID-19 and spontaneous pneumothorax: a survival analysis. Journal of Cardiothoracic Surgery 2023; 18(1): 211 / doi: 10.1186/s13019-023-02331-0.
10. Tüzün T, Ekinci Y. Rare complication spontaneous pneumothorax and pneumomediastinum in COVID-19 patients: A single center experience. J Infect Dev Ctries 2023; 17(12): 1682-1689 / doi: 10.3855/jidc.18048.
11. Ahmad Khan A, Zahid M, Ahmad Alhiyari M, et al. Demographics, clinical characteristics, and recurrence rate of patients with primary spontaneous pneumothorax at a tertiary care center in Qatar. Qatar Med J 2022; 2022(4): 56 / doi: 10.5339/qmj.2022.56.
12. Chong WH, Saha BK, Hu K, Chopra A. The incidence, clinical characteristics, and outcomes of pneumothorax in hospitalized COVID-19 patients: A systematic review. Heart Lung 2021; 50(5): 599-608 / doi: 10.1016/j.hrtlng.2021.04.005.
13. Çoraplı G, Tekin V. Evaluation of Patients Who Developed Pneumothorax Due to COVID-19. Diag-nostics (Basel) 2022; 12(9): 2140 / doi: 10.3390/diagnostics12092140.
14. Ali N, Islam F. The Effects of Air Pollution on COVID-19 Infection and Mortality-A Review on Recent Evidence. Front Public Health 2020; 8: 580057 / doi: 10.3389/fpubh.2020.580057.
15. Özgel M, Gülçek I, Ağar M, Ulutaş H. Pneumothorax as a Poor Prognostic Indicator in COVID-19 in Turkey: A Propensity Score Matching Analysis. Niger J Clin Pract 2024; 27(8): 958-964 / doi: 10.4103/ njcp.njcp_785_23.
16. Yang Y, Song Y, Hou D. Obesity and COVID-19 Pandemics: Epidemiology, Mechanisms, and Man-agement. Diabetes Metab Syndr Obes 2023; 16: 4147-4156 / doi: 10.2147/ DMSO. S441762.

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