CUT-OFF VALUES OF BODY FAT PERCENTAGE AND INSULIN FOR PREDICTING LOW ADIPONECTIN / LEPTIN RATIO

Authors

  • Ivona MITU ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Corina Paraschiva CIOBANU ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • A.D. COSTACHE ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Minerva Codruta BADESCU ‟Grigore Popa” University of Medicine and Pharmacy Iași
  • Cristina Daniela DIMITRIU ‟Grigore Popa” University of Medicine and Pharmacy Iași

DOI:

https://doi.org/10.22551/xwj10j39

Abstract

This study aims to establish a reliable parameter and its optimal cut-off point for accurately estimating adipose tissue dysfunctionality in apparently healthy, but abdominally obese subjects. Materials and methods: The 104 subjects included in the study, all with no prior chronic diseases, underwent biochemical (TG, HDL-c, glucose, insulin, adiponectin, leptin) and anthropometric measurements (waist circumference, height, adipose tissue percentage). A ROC curve was performed to assess the overall performance of these parameters to determine the dysfunctionality of the adipocytes, as assessed by adiponectin: leptin ratio (ALR) lower than 0.5. Logistic regression identified models that included 2 or 3 parameters to further increase the accuracy. The software Excel and SPSS were used for the statistical analysis. Results: From all individual parameters, trunk adipose tissue percentage had an AUC value of 0.812, suggesting a high accuracy for predicting a value of ALR<0.5. The optimal cut-off point for trunk adipose tissue percentage was established at 42.45% with a sensitivity of 0.725 and a specificity of 0.766. A higher AUC (0.857) was observed for the model that included whole-body adipose tissue (cut-off 41.7%) and insulin (cut-off 14.6 μU/mL), while the highest accuracy (AUC=0.889) was reported in the model for metabolically unhealthy non-obese subjects. Conclusions: Apparently healthy individuals, but abdominally obese, report adipocyte dysfunctionality together with high cardiometabolic risk at values for trunk adipose tissue percentage surpassing 42.45%, or combined values of 41.7% for whole-body adipose tissue and 14.6 μU/mL for insulin

Author Biographies

  • Ivona MITU, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    Department of Morpho-Functional Sciences (II)

  • Corina Paraschiva CIOBANU, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    Department of Morpho-Functional Sciences (II)

  • A.D. COSTACHE, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    Department of Medical Specialties (I) 

  • Minerva Codruta BADESCU, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    Department of Medical Specialties (I)

  • Cristina Daniela DIMITRIU, ‟Grigore Popa” University of Medicine and Pharmacy Iași

    Faculty of Medicine
    Department of Morpho-Functional Sciences (II)

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Additional Files

Published

2025-04-07

Issue

Vol. 129 No. 1 (2025): The Medical-Surgical Journal

Section

INTERNAL MEDICINE - PEDIATRICS

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