RELATIONSHIP BETWEEN FRACTION OF EXHALED NITRIC OXIDE AND SPIROMETRY PARAMETERS IN ASTHMA

Authors

  • C. C. GRIGORAȘ Clinical Hospital of Pneumology Iasi, Romania
  • Adriana GRIGORAȘ Grigore T. Popa University of Medicine and Pharmacy Iasi, Romania
  • C. G. TARȚĂU Grigore T. Popa University of Medicine and Pharmacy Iasi, Romania
  • Cornelia AMALINEI Grigore T. Popa University of Medicine and Pharmacy Iasi, Romania

DOI:

https://doi.org/10.22551/MSJ.2026.02.05

Abstract

Aim: Asthma is a chronic airway inflammatory disease with significant social and economic impacts, being associated with a high annual rate of premature deaths. Asthma severity and response to inhaled corticosteroids therapy can be assessed by spirometry parameters and fractional exhaled nitric oxide (FeNO) evaluation. The aim of this study was to evaluate the relationship between spirometry parameters and FeNO values in a group of asthmatic patients. Materials and methods: We performed a retrospective analysis on 124 patients with history of asthma of different degrees of severity. All patients have been classified according to the last Global Initiative for Asthma (GINA) criteria and had a complete spirometry and a FeNO measurement. Results: The analyzed cases showed a female predominance (62.9%) and a mean patient age of 50.6±16.0 years. A significant association between Forced Expiratory Volume in one second (FEV1) values (F = 231.167, p < 0.001) or FEV1/FCV ratio (F = 52.630, p < 0.001) and the degree of asthma control was observed in all patients, regardless of inhaled corticosteroids administration. An inverse correlation between FEV1 and FeNO values (r = −0.52, p < 0.01) was registered. Conclusions: Spirometry parameters and FeNO represent valuable tools in the management of asthma, with higher FeNO values being associated with impaired lung function.

Author Biographies

  • C. C. GRIGORAȘ, Clinical Hospital of Pneumology Iasi, Romania

    Grigore T. Popa University of Medicine and Pharmacy Iasi, Romania

  • Adriana GRIGORAȘ, Grigore T. Popa University of Medicine and Pharmacy Iasi, Romania

    Institute of Forensic Medicine Iasi

  • Cornelia AMALINEI, Grigore T. Popa University of Medicine and Pharmacy Iasi, Romania

    Institute of Forensic Medicine Iasi

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Additional Files

Published

2026-06-01

Issue

Vol. 130 No. 2 (2026): The Medical-Surgical Journal

Section

INTERNAL MEDICINE - PEDIATRICS

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