PERIOPERATIVE OUTCOMES OF LAPAROSCOPIC ADRENALECTOMY FOR ADRENAL TUMORS: A SINGLE-CENTER RETROSPECTIVE STUDY

Authors

  • V. BERNIC Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania
  • Maria-Christina UNGUREANU Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania
  • D. O. BUESCU Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania
  • Adelina TANEVSKI Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania
  • Andreea LUDUSANU “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania
  • Roxana CHIRIAC Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania
  • M. ZABARA Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania
  • C. D. LUPASCU Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania

DOI:

https://doi.org/10.22551/MSJ.2026.03.10

Abstract

Laparoscopic adrenalectomy has become the preferred minimally invasive approach for most selected adrenal tumors. The evaluation of perioperative outcomes in a university center is essential for assessing the safety, feasibility, and clinical relevance of this technique in routine surgical practice. Aim: To assess the perioperative outcomes of laparoscopic adrenalectomy in patients with adrenal tumors treated in a university center. Materials and methods: We performed a retrospective single-center study including adult patients with adrenal tumors who underwent laparoscopic adrenalectomy between 2020 and 2025 at Sf. Spiridon County Clinical Emergency Hospital, Iași. Demographic and clinical characteristics, hormonal status, tumor size, perioperative parameters, and final histopathological findings were analyzed. Results: The study included 52 patients who underwent 53 laparoscopic adrenalectomies. The mean age was 56.8 years, and 67.3% of patients were female. Non-functioning tumors represented 50.0% of cases. Mean tumor size on preoperative imaging was 4.0 cm, mean operative time was 139.7 minutes, and mean estimated blood loss was 93.6 mL. Conversion to open surgery occurred in 26.4% of procedures and was associated with older age (p=0.045), longer operative time (p<0.001), greater estimated blood loss (p<0.001), prolonged drainage (p<0.001), and longer hospital stay (p=0.013). Postoperative complications occurred in 9.4% of procedures, and no 30-day mortality was recorded. Conclusions: Laparoscopic adrenalectomy is a feasible and safe approach for selected adrenal tumors, providing favorable postoperative outcomes in a university surgical center.

Author Biographies

  • V. BERNIC, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania

    Sf. Spiridon County Clinical Emergency Hospital, Iasi, Romania

  • Maria-Christina UNGUREANU, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania

    Sf. Spiridon County Clinical Emergency Hospital, Iasi, Romania

  • D. O. BUESCU, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania

    Sf. Spiridon County Clinical Emergency Hospital, Iasi, Romania

  • Adelina TANEVSKI, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania

    Sf. Spiridon County Clinical Emergency Hospital, Iasi, Romania

  • Roxana CHIRIAC, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania

    Sf. Spiridon County Clinical Emergency Hospital, Iasi, Romania

  • M. ZABARA, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania

    Sf. Spiridon County Clinical Emergency Hospital, Iasi, Romania

  • C. D. LUPASCU, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania

    Sf. Spiridon County Clinical Emergency Hospital, Iasi, Romania

References

1. Sherlock M, Scarsbrook A, Abbas A, et al. Adrenal incidentaloma. Endocr Rev 2020; 41(6): 775-820.

2. Fassnacht M, Tsagarakis S, Terzolo M, et al. European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors. Eur J Endocrinol 2023; 189(1): G1-G42.

3. Chatzellis E, Kaltsas G. Adrenal incidentaloma. In: Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext. South Dartmouth (MA): MDText.com, Inc., 2024.

4. Park SY, Kim JH. Recent updates on the management of adrenal incidentalomas. Endocrinol Metab (Seoul) 2023; 38(6): 812-823.

5. Cesmebasi A, Du Plessis M, Iannatuono M, Shah S, Tubbs RS, Loukas M. A review of the anat-omy and clinical significance of adrenal veins. Surg Radiol Anat 2014; 36(2): 125-132.

6. Gagner M. Laparoscopic adrenalectomy. Surg Clin North Am 1996; 76(3): 523-537.

7. Uludağ M, Aygün N, İșgör A. Surgical indications and techniques for adrenalectomy. Sisli Etfal Hastan Tip Bul 2020; 54(1): 8-22.

8. Funder JW, Carey RM, Mantero F, et al. The management of primary aldosteronism: case detec-tion, diagnosis, and treatment: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2016; 101(5): 1889-1916.

9. Lenders JWM, Duh QY, Eisenhofer G, et al. Pheochromocytoma and paraganglioma: An Endo-crine Society clinical practice guideline. J Clin Endocrinol Metab 2014; 99(6): 1915-1942.

10. Pacak K, Tella SH. Pheochromocytoma and paraganglioma. In: Endotext. South Dartmouth (MA): MDText.com, Inc., 2018.

11. Fassnacht M, Dekkers OM, Else T, et al. European Society of Endocrinology clinical practice guidelines on the management of adrenocortical carcinoma in adults, in collaboration with EN-SAT. Eur J Endocrinol 2018; 179(4): G1-G46.

12. Gagner M, Lacroix A, Bolté E. Laparoscopic adrenalectomy in Cushing’s syndrome and pheo-chromocytoma. N Engl J Med 1992; 327(14): 1033.

13. Gumbs AA, Gagner M. Laparoscopic adrenalectomy. Best Pract Res Clin Endocrinol Metab 2006; 20(3): 483-499.

14. Mellon MJ, Sundaram CP. Laparoscopic adrenalectomy: surgical techniques. Indian J Urol 2008; 24(4): 583-589.

15. Smith CD, Weber CJ, Amerson JR. Laparoscopic adrenalectomy: new gold standard. World J Surg 1999; 23(4): 389-396.

16. Miller BS, Gauger PG, Hammer GD. The evolving role of laparoscopic adrenalectomy in the management of adrenal disease. Surg Clin North Am 2012; 92(6): 1243-1257.

17. Walz MK, Alesina PF, Wenger FA, et al. Posterior retroperitoneoscopic adrenalectomy-results of 560 procedures in 520 patients. Surgery. 2006; 140(6): 943-950.

18. Rubinstein M, Gill IS, Aron M, et al. Prospective, randomized comparison of trans peritoneal versus retroperitoneal laparoscopic adrenalectomy. Eur Urol 2005; 174(2): 442-445.

19. Chiu AW. Laparoscopic retroperitoneal adrenalectomy: clinical experience with 120 consecutive cases. Asian J Surg 2003; 26(3): 139-144.

20. Porpiglia F, Fiori C, Daffara F, Zaggia B, Bollito E, Volante M. Retrospective evaluation of the outcome of open versus laparoscopic adrenalectomy for large (>5 cm) adrenal tumors: results from a single center. Eur Urol 2010; 57(5): 873-878.

21. Brix D, Allolio B, Fenske W, et al. Laparoscopic versus open adrenalectomy for adreno-cortical carcinoma: surgical and oncologic outcome in 152 patients. Eur Urol 2015; 68(4): 609-615.

22. Brunaud L, Ayav A, Zarnegar R, Bresler L, Klein M. Robotic adrenalectomy: an evidence-based review. Surg Endosc 2014; 28(1): 19-30.

23. Shen ZJ, Chen SW, Wang S, Jin XD, Chen J, Zhu Y, Zhang RM. Predictive factors for open conversion of laparoscopic adrenalectomy: a 13-year review of 456 cases. J Endourol 2007; 21(11): 1333-1337.

24. Vidal O, Saavedra-Perez D, Martos JM, et al. Risk factors for open conversion of lateral trans peritoneal laparoscopic adrenalectomy: retrospective cohort study of the Spanish Adrenal Surgery Group (SASG). Surg Endosc 2020; 34(8): 3690-3695.

25. Hou Q, Zhang B, Luo Y, Wang P, Yang S, Shang P. Predictive factors for conversion from laparoscopic adrenalectomy to open surgery: a 9-year review of 911 cases. J Laparoendosc Adv Surg Tech 2023; 33(1): 38-43.

Additional Files

Published

2026-09-28