THE EFFECT OF COBALT CHLORIDE PRECONDITIONING ON PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY
Abstract
Introduction: Recent studies indicate that Cobalt Chloride (CoCl2) modulates mitochondrial activity. There is emerging data suggesting that Paclitaxel-induced peripheral neuropathy (PIPN) is a consequence of the drug's mitochondrial toxicity. AIM: to assess the effect of CoCl2 preconditioning on PIPN in an animal model. Material and method: PIPN was induced by 7 daily consecutive i.p. Paclitaxel (PXT) administrations. Male BALB/c mice were divided into three groups as follows: group A - CoCl2 (12.5 mg/kg b.w.) for three weeks (preconditioning) followed by 1 week of PXT, group B - saline for three weeks, followed by 1 week of PXT and group C - saline for four weeks. Thermal and mechanical allodynia were assessed by means of paw withdrawal latency (PWL). Results: In group A, CoCl2 preconditioning lead to a decrease in both thermal and mechanical PWLs. 7 days after the last dose of PXT, however, values returned to normal in group A and allodynia for both thermal and mechanical stimuli was noted in group B (p<0.05). Conclusions: CoCl2 preconditioning seems to protect against PIPN. Although CoCl2 administration decreased thermal and mechanical PWLs, subsequent P administration did not lead to the persistent mechanical and thermal allodynia that was noted in the P-alone group. Further studies are required for determining the exact relationship between CoCl2 and PIPN.
References
2. Cavaletti G, Cavalletti E, Oggioni N, Sottani C, Minoia C, D’Incalci M, et al. Distribution of paclitaxel within the nervous system of the rat after repeated intravenous administration. Neurotoxicology. 2000; 21(3): 389–393.
3. Flatters SJL, Bennett GJ. Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: evidence for mitochondrial dysfunction. Pain. 2006; 122(3): 245–257.
4. Singh M, Shukla D, Thomas P, Saxena S, Bansal A. Hypoxic preconditioning facilitates acclimatization to hypobaric hypoxia in rat heart. J Pharm Pharmacol. 2010; 62(12): 1729–1739.
5. Matsumoto M, Makino Y, Tanaka T, Tanaka H, Ishizaka N, Noiri E, et al. Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats. J Am Soc Nephrol. 2003; 14(7): 1825–1832.
6. Shrivastava K, Shukla D, Bansal A, Sairam M, Banerjee PK, Ilavazhagan G. Neuroprotective effect of cobalt chloride on hypobaric hypoxia-induced oxidative stress. Neurochem Int. 2008; 52(3): 368–375.
7. Saxena S, Shukla D, Bansal A. Augmentation of aerobic respiration and mitochondrial biogenesis in skeletal muscle by hypoxia preconditioning with cobalt chloride. Toxicol Appl Pharmacol. 2012 Nov 1; 264(3): 324–34.
8. Jones NM, Bergeron M. Hypoxic preconditioning induces changes in HIF-1 target genes in neonatal rat brain. J Cereb Blood Flow Metab. 2001; 21(9): 1105–1114.
9. Alexa T, Luca A, Dondas A, Bohotin CR. Preconditioning with cobalt chloride modifies pain perception in mice. Exp Ther Med. 2015; 9(4): 1465–1469.
10. Hargreaves K, Dubner R, Brown F, Flores C, Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain. 1988; 32(1): 77–88.
11. Brenchat A, Nadal X, Romero L, Ovalle S, Muro A, Sánchez-Arroyos R, et al. Pharmacological activation of 5-HT7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity. Pain. 2010;149(3): 483–494.
12. Apostoli P, Catalani S, Zaghini A, Mariotti A, Poliani PL, Vielmi V, et al. High doses of cobalt induce optic and auditory neuropathy. Exp Toxicol Pathol. 2013; 65(6): 719–727.
13. Nieto FR, Cendán CM, Cañizares FJ, Cubero MA, Vela JM, Fernández-Segura E, et al. Genetic inactivation and pharmacological blockade of sigma-1 receptors prevent paclitaxel-induced sensory-nerve mitochondrial abnormalities and neuropathic pain in mice. Mol Pain. 2014; 10(1): 11.
14. Janes K, Doyle T, Bryant L, Esposito E, Cuzzocrea S, Ryerse J, et al. Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase. Pain. 2013;154(11): 2432–2440.
15. Zhang X, Zhang S, Zhu S, Chen S, Han J, Gao K, et al. Identification of mitochondria-targeting anticancer compounds by an in vitro strategy. Anal Chem. 2014; 86(11): 5232–5237.
16. Andre N, Braguer D, Brasseur G, Goncalves A, Lemesle-Meunier D, Guise S, et al. Paclitaxel Induces Release of Cytochrome c from Mitochondria Isolated from Human Neuroblastoma Cells. Cancer Res. 2000; 60(19): 5349–5353.
17. Luca A, Alexa T, Dondaş A, Andron G, Bădescu M, Alexa ID, et al. Pain modulation by curcumin and ascorbic acid in mice. Rev Med Chir Soc Med Nat Iasi 2014; 118(2): 346–351.
18. Vissers K, Hoffmann V, Geenen F, Biermans R, Meert T. Is the second phase of the formalin test useful to predict activity in chronic constriction injury models? A pharmacological comparison in different species. Pain Pract. 2003; 3(4): 298–309.
19. Arcan O, Ciobică A, Bild W, Dobrin R, Petrariu FD, Cojocaru D. Interactions between the oxidative and nitrosative stress in nociceptive processing in rat. Rev Med Chir Soc Med Nat Iasi. 2014; 116(3): 867–74.
20. Caltana L, Merelli A, Lazarowski A, Brusco A. Neuronal and glial alterations due to focal cortical hypoxia induced by direct cobalt chloride (CoCl2) brain injection. Neurotox Res. 2009; 15(4): 348–358.
21. Kanngiesser M, Mair N, Lim H-Y, Zschiebsch K, Blees J, Häussler A, et al. Hypoxia-inducible factor 1 regulates heat and cold pain sensitivity and persistence. Antioxid Redox Signal. 2014; 20(16): 2555–2571.
22. Østergaard L, Finnerup NB, Terkelsen AJ, Olesen RA, Drasbek KR, Knudsen L, et al. The effects of capillary dysfunction on oxygen and glucose extraction in diabetic neuropathy. Diabetologia. 2015; 58(4): 666–677.
23. Fraser CL. Obstructive sleep apnea and optic neuropathy: is there a link? Curr Neurol Neurosci Rep. 2014; 14(8): 465.
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