DETECTION OF HUMAN PAPILLOMAVIRUS IN HEAD AND NECK SQUAMOUS CELL CARCINOMAS: A LITERATURE REVIEW

Authors

  • I. JELIHOVSCHI University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi
  • Aida Corina BADESCU University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi
  • Simona Elena TUCALIUC University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi
  • Luminita Smaranda IANCU University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi

Keywords:

HEAD AND NECK CANCER, HPV TESTING, BIOMARKERS

Abstract

Human papilloma viruses (HPV) are the most common sexually transmitted viruses. There is mounting evidence that incriminates HPV as a risk factor for malignant transformation of oropharyngeal epithelium. In 2011 the International Research Agency of Cancer and National Cancer Institute (USA) declared HPV-16 as an independent risk factor for oropharyngeal squamous cell carcinoma (OPSCC). Leaders in the field of HPV research admit that this subtype of head and neck cancer is a sexually transmitted entity and its global incidence is on the rise. In the 1980s, clinicians observed a new group of patients with head and neck squamous cell carcinoma (HNSCC) independent of tobacco smoking or alcohol use. The new HNSCC patient is a middle-aged man, non-smoker, non-drinker with higher social status and the suspected risk factors for HNSCC being related to sexual practices (oral sex, multiple sexual partners, unprotected sex and drug use). Routine HPV testing of HNSCC patients is seriously considered as HPV-positive oropharyngeal cancers comprise a distinct molecular, clinical and pathologic entity that has a markedly better prognosis than HPV-negative oropharyngeal cancers. The current treatment protocols for OPSCC include radiation, chemo-therapy and surgery alone or in combination, involving high toxicity levels. Future therapeutic concepts for OPSCC may be personalized in relation to HPV-status to avoid unnecessary toxicity. The current review summarizes the contemporary trends in the diagnosis of HPV-related head and neck cancers, presenting the advantages and disadvantages of the main methods.

Author Biographies

  • I. JELIHOVSCHI, University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi

    Faculty of Medicine
    Department of Medical Specialties (II)

  • Aida Corina BADESCU, University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi

    Faculty of Medicine
    Department of Medical Specialties (II)

  • Simona Elena TUCALIUC, University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi

    Faculty of Medicine
    Department of Medical Specialties (II)

  • Luminita Smaranda IANCU, University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi

    Faculty of Medicine
    Department of Medical Specialties (II)

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Additional Files

Published

2015-06-30

Issue

Vol. 119 No. 2 (2015): The Medical-Surgical Journal

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PREVENTIVE MEDICINE - LABORATORY

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