RETROSPECTIVE EPIDEMIOLOGIC RESEARCH ON PREVALENCE OF INFECTIONS IN SURGICALLY TREATED ONCOLOGIC PATIENTS

Authors

  • Elenis MANAFU University Transilvania - Braşov
  • Irina JARI University of Medicine and Pharmacy”Grigore T. Popa”- Iaşi
  • Raluca Mihaela FILIMON Regional Institute of Oncology, Iași
  • Alina MANOLE University of Medicine and Pharmacy”Grigore T. Popa”- Iaşi

Abstract

The aim of this work was the retrospective study of the frequency of infections in surgically treated oncologic patients. Material and methods: Our research included 753 oncologic patients treated at the Second Surgical Clinic of the Regional Institute of Oncology, Iași, between January 2013 and December 2014, with the selection of cases which had infectious complications. Results: The lot of patients was structured in 7 age groups and the most frequent oncologic patients had ages between 60-79 years. The most frequent malignancies were large bowel, breast, rectal, esophageal cancers, malignant hemopathies, gastric and liver malignant tumors. In our lot of 753 oncologic patients we depicted 113 (15.01%) infections. Conclusions: Our study proved that the anatomic location of the cancer, the hospitalization duration and the number of the hospitalizations has an important role in appearance of the infectious complications. The gastrointestinal malignant tumors were the most frequent malignancies associated with postoperative infections. The patients with gastrointestinal cancers from urban area, with ages between 50 and 79 years had the highest risk of infectious complications. For main causative organism was proved a high sensitivity for colistin. Clinical, paraclinical and epidemiological exams did not emphasize any decisive factors; we took into account the risks of infection during multiple pre-, intra- and postoperative procedures; all these have been associated with increased receptivity of immunosuppressed oncologic patients.

Author Biographies

  • Elenis MANAFU, University Transilvania - Braşov

    Faculty of Medicine
    Department de Epidemiology

  • Irina JARI, University of Medicine and Pharmacy”Grigore T. Popa”- Iaşi

    Faculty of Medicine
    Department of Surgery

  • Raluca Mihaela FILIMON, Regional Institute of Oncology, Iași

    Department of Epidemiology

  • Alina MANOLE, University of Medicine and Pharmacy”Grigore T. Popa”- Iaşi

    Faculty of Medicine
    Department of Preventive Medicine and Interdisciplinarity

References

1. DaPrada AG, Preti P. Complicazioni infettive. In: Bonadonna G, (ed.). Medicina oncologica. 7ma ed. Milano: Masson, 2003:1013-1064.
2. Miron L. Terapia oncologică-opțiuni bazate pe dovezi. Editura Institutul European, Iași, 2008, 799-919.
3. Xiaomei M, Herbert Y. Epidemiologic methods. In: DeVita VT Jr, Rosenberg S, Hellman SA (eds.) Cancer: principles and practice of oncology. 9th ed. Philadelphia: Lippincott, Williams & Wilkins, 2010: 233-239.
4. Thun MJ, Jemal A, Ward E. Global cancer incidence and mortality. In: DeVita, Hellman, Rosenberg’s. Cancer: principles and practice of oncology. 9th ed. Philadelphia: Lippincott, Williams & Wilkins, 2010: 241-259.
5. Miftode E, Dorneanu O, Leca D, Teodor A, Mihalache D, Filip O, Luca V. Profilul de rezistenţă al E. coli şi Klebsiella spp. din infecţii urinare în Spitalul de Boli Infecţioase Iaşi. Rev Med Chir Soc Med Nat Iasi 2008; 112(2): 478-483.
6. Ciufecu C. Infecțiile gazdelor imunocompromise. In: Tratat de epidemiologie a bolilor transmisibile. Ivan A (ed.), Editura Polirom, Iași, 2002, 803-807.
7. Miron L, Filimon R, Petrariu FD, Matei MC. Clostridium difficile epidemic outbreak in an oncology unit. Rev Med Chir Soc Med Nat Iasi 2014; 118(1): 165-171.
8. Lange WL. Infectious complications. In: Casciato DA, ed. Manual of clinical oncology. 5th ed. Phila-delphia: Lippincott, Williams & Wilkins, 2005: 683-692.
9. Safdar N, Crnich CJ, Maki DG. Infectious complications of cancer therapy. In: Chang AE, Ganz PA, Hayes DF (eds.). Oncology - an evidence based approach. New York: Springer, 2006:1363-1400.
10. Segal BH, Walsh J, Gea-Bannacloche JC, et al. Infections in the cancer patients. In: DeVita VT Jr, Rosenberg S, Hellman SA (eds.) Cancer: principles and practice of oncology. 7th ed. Philadelphia: Lippincott, Williams & Wilkins, 2005: 2461-2514.
11. Schimp S. Infectious in the cancer patients diagnosis prevention and treatment. In: Principles and practices of infectious diseases. Mandell, Douglas, Bennett (coord.). Churchill-Livingstone, 2000, 2666-2675.

Additional Files

Published

2015-06-30

Issue

Vol. 119 No. 2 (2015): The Medical-Surgical Journal

Section

PREVENTIVE MEDICINE - LABORATORY

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