HYPOGLYCEMIA INDUCED BY ANTIDIABETIC SULFONYLUREAS

Authors

  • Luminita CONFEDERAT University of Medicine and Pharmacy”Grigore T. Popa”– Iaşi
  • Sandra CONSTANTIN University of Medicine and Pharmacy”Grigore T. Popa”– Iaşi
  • Florentina LUPASCU University of Medicine and Pharmacy”Grigore T. Popa”– Iaşi
  • Andreea PANZARIU University of Medicine and Pharmacy”Grigore T. Popa”– Iaşi
  • Monica HANCIANU University of Medicine and Pharmacy”Grigore T. Popa”– Iaşi
  • Lenuta PROFIRE University of Medicine and Pharmacy”Grigore T. Popa”– Iaşi

Abstract

Diabetes mellitus is a major health problem due to its increasing prevalence and life-threatening complications. Antidiabetic sulfonylureas represent the first-line drugs in type 2 diabetes even though the most common associated risk is pharmacologically-induced hypoglycemia. In the development of this side effect are involved several factors including the pharmacokinetic and pharmacodynamic profile of the drug, patient age and behavior, hepatic or renal dysfunctions, or other drugs associated with a high risk of interactions. If all these are controlled, the risk-benefit balance can be equal to other oral antidiabetic drugs.

Author Biographies

  • Luminita CONFEDERAT, University of Medicine and Pharmacy”Grigore T. Popa”– Iaşi

    Faculty of Pharmacy
    Department of Pharmaceutical Sciences I

  • Sandra CONSTANTIN, University of Medicine and Pharmacy”Grigore T. Popa”– Iaşi

    Faculty of Pharmacy
    Department of Pharmaceutical Sciences I

  • Florentina LUPASCU, University of Medicine and Pharmacy”Grigore T. Popa”– Iaşi

    Faculty of Pharmacy
    Department of Pharmaceutical Sciences I

  • Andreea PANZARIU, University of Medicine and Pharmacy”Grigore T. Popa”– Iaşi

    Faculty of Pharmacy
    Department of Pharmaceutical Sciences I

  • Monica HANCIANU, University of Medicine and Pharmacy”Grigore T. Popa”– Iaşi

    Faculty of Pharmacy
    Department of Pharmaceutical Sciences II

  • Lenuta PROFIRE, University of Medicine and Pharmacy”Grigore T. Popa”– Iaşi

    Faculty of Pharmacy
    Department of Pharmaceutical Sciences I

References

1. Lupașcu FG, Geangalău IM, Pânzariu A, Profire L. Incretin modulators, a new perspective in diabetes mellitus treatment. Rev. Med. Chir 2012; 116(2): 630-634.
2. Sonia TA, Sharma CP. Oral Delivery of Insulin. Woodhead Publishing, 2014, 1-57.
3. Guariguata L, Whiting DR, Hambleton I et al. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diab Res Clin Pract 2014; 103(2): 137-149.
4. De Marzio DH, Navarro VJ. Hepatotoxicity of Cardiovascular and Antidiabetic Drugs. In: Kaplowitz N, DeLeve L. Drug-Induced Liver Disease. Academic Press, 2013, 519-540.
5. Virally M, Blickle JF, Girard J, Halimi S, Simon D, Guillausseau PJ. Type 2 diabetes melliuts: epi-demiology, pathophysiology, unmet needs and therapeutical perspectives. Diab Metab 2007; 33: 231-244.
6. Strugaru AM, Botnariu G, Agoroaei L, Grigoriu IC, Butnaru E. Metformin induced lactic acidosis – particularities and course. Rev. Med. Chir 2013; 117(4): 1035-1042.
7. Nathan DM. Finding new treatments for diabetes – how many, how fast... how good? N Engl J Med 2007; 356: 437-440.
8. Garcia Reyes R, Raya PM. How to prevent and treat pharmacological hypoglycemias. Rev Clin Esp. 2014; 214(4): 202-208.
9. Kudaravalli J, Vijayalakshimi G, Kishore KK. Safety and efficacy of sulfonylurea drugs in type 2 diabetes mellitus. Apollo Medicine 2013; 10: 65-168.
10. Aronson JK. Meyler’s Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reac-tions and Intertactions. Elsevier Science, 2006, 3230-3242.
11. Del Prato S. Sulfonylureas in the therapy of type 2 diabetes mellitus: where do we stand today? Metab Clin Experim 2006; 55(Suppl 1): S1-S28.
12. Ovalle F. Cardiovascular Implications of Antihyperglycaemic Therapies for Type 2 Diabetes. Clin Therap 2011; 33(4): 393-407.
13. Holman RR. Long-term efficacy of sulfonylureas: a United Kingdom Prosective Diabetes Study perspective. Metab Clin Experim 2006; 55(Suppl 1): S2-S5.
14. Thomas JA, Thomas MJ. Insulin and Hypoglycemic Drugs. In: Bittar E. Molec Cellular Pharmacol. Elsevier Science, 1997, 601-622.
15. Thisted H, Johnsen SP, Rungby J. Sulfonylureas and the risk of myocardial infarction. Metab Clin Experim 2006; 55(Suppl 1): S16-S19.
16. Del Prato S, Pulizzi N. The place of sulfonylureas in the therapy for type 2 diabetes mellitus. Metab Clin Experim 2006; 55(Suppl 1): S20-S27.
17. Chounta A, Zouridakis S, Ellinas C et al. Cholestatic liver injury after glimepiride therapy. J Hepatol 2005; 42: 944-946.
18. Belcher G, Lambert C, Edwards G, Urquhart R, Matthews DR. Safety and tolerability of pioglitazone, metformin and gliglazide in the treatment of type 2 diabetes. Diab Res Clin Pract 2005; 70: 53-62.
19. Graveling AJ, Frier BM. Hypoglycaemia: An overview. Primary Care Diab 2009; 3: 131-139.
20. Seaquist ER, Anderson J, Childs B et al. Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society. J Clin Endocrinol Metab 2013; 98: 1845-1859.
21. Brutsaert E, Carey M, Zonszein J. The clinical impact of inpatient hypoglycemia. J Diab Complic 2014; 28: 565-572.
22. Ferner RE, Neil HA. Sulfonylureas and hypoglycemia. BMJ 1988; 296: 949-950.
23. Ammon HPT, Haring HU, Keller M, Laube H, Mostfaf L. Compound Acting on Insulin Secretion: Sulphonylureas. In: Testa B, Meyer U. Advances in Drug Research. Academic Press, 1996, 107-136.
24. Srinivasan BT, Davies M. Managing Glycaemia in Diabetes. Medicine 2014; 42(12): 711-717.
25. Germino FW. Noninsulin Treatment of Type 2 Diabetes mellitus in Geriatric Pacients: A review. Clin Therap 2011; 33(12): 1868-1882.
26. Doucet J. Use of antidiabetic drugs in eldery patiens. Diab Metab 2005; 31: 5S98-5S104.
27. Cornish W. Safe and Appropriate Use of Insulin and Other Antihyperglycemic Agents in Hospital. Can J Diab 2014; 38: 94-100.

Additional Files

Published

2015-06-30

Issue

Vol. 119 No. 2 (2015): The Medical-Surgical Journal

Section

PHARMACY

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