RARE PEDIATRIC CUTANEOUS T-CELL LYMPHOMA

Authors

  • Mirabela SUBOTNICU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Adriana MOCANU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Magdalena STARCEA “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Doina MIHAILA “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Tatiana TARANU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Anca IVANOV “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Abstract

We describe a rare case of an adolescent with T-cell cutaneous lymphoma, having a history of intense pruriginous, erythematous and hyperpigmented skin lesions. Several considerations regarding diagnostic work-up and treatment must be emphasized. Erythematous, pruritic patches, unresponsive to common topical/general treatment should raise the suspicion of more serious immuno-allergic or neoplastic conditions, among which, cutaneous lymphoma could be a rare, but a realistic possibility in pediatric field. Long term follow-up by a pediatric haemato-oncologist and dermatologist team is mandatory for these patients.

Author Biographies

  • Mirabela SUBOTNICU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Mother and Child Medicine
    “St. Maria” Emergency Children's Hospital Iasi

  • Adriana MOCANU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Mother and Child Medicine
    “St. Maria” Emergency Children's Hospital Iasi

  • Magdalena STARCEA, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Mother and Child Medicine
    “St. Maria” Emergency Children's Hospital Iasi

  • Doina MIHAILA, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Mother and Child Medicine
    “St. Maria” Emergency Children's Hospital Iasi

  • Tatiana TARANU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Medical Specialties (III)
    “Romanian Railways” Clinical Hospital, Iasi

  • Anca IVANOV, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Mother and Child Medicine
    “St. Maria” Emergency Children's Hospital Iasi

References

1. Cobzeanu MD, Costinescu V, Rusu CD, Mihailovici S, Miron L, Paduraru D, Arama A. Laryn-gothaheal non-Hodgkin’s lymphoma. Chirurgia 2010; 105(1): 131-136.
2. Kempf W, Kazakov DV, Belousova IE, Mitteldorf C, Kerl K. Paediatric cutaneous lymphomas: a review and comparison with adult counterparts. J Eur Acad Dermatol Venereol 2015; 29: 1696-1709.
3. Ferenczi K, Makker HS. Cutaneous lymphoma: Kids are not just little people. Clin Dermatol 2016; 34(6): 749-759.
4. Gafton B, Porumb V, Ungurianu S, Marinca MV, Cocea C, Croitoru A, Balan G, Miron N, Ciuleanu TE, Miron L. Hepatocellular carcinoma: insight in the biological treatment beyond sorafenib. J BUON 2014; 19(4): 858-866
5. Peters MS et al. Mycosis fungoides in children and adolescents. J.Am.Acad.Dermatol 1990; 22: 1011-1018.
6. Bagherani N, Smoller BR. An overview of cutaneous T cell lymphomas. F1000Res. 2016; 28: 5-9.
7. Ceppi F, Pope E, Nqan B, Abla O. Primary cutaneous lymphomas in children and adolescents. Pediatr Blood Cancer 2016; 63(11): 1886-1894.
8. Olsen E et al. Revisions to the staging and classification of mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC). Blood 2007; 110: 1713-1722.
9. Miron I, Diaconescu S, Aprodu G, Ioniuc I, Diaconescu MR, Miron L. Diagnostic Difficulties in a Pediatric Insulinoma: A Case Report. Medicine. 2016; 95(11): 3045-3049.
10. Miron I, Mihaila D, Aprodu G, Miron L, Plamadeala P, Moisa SM. Immunoproliferative small intes-tinal disease versus colonic monoblastic sarcoma in a 2-year-old boy. Rom J Morphol Embryol 2009; 50(4): 733-738.
11. Nemes RM, Pop CS, Calagiu D, Dobrin D, Chetroiu D, Jantea P, Postolache P. Anemia in inflamatory bowel disease more than an extraintestinal complication. Rev. Med. Chir. Soc. Med. Nat. Iasi 2016; 120(1) :34:39.
12. Hughes CF, Newland K, McCormack C, Lade S, Prince HM. Mycosis fungoides and Sézary syn-drome: Current challenges in assessment, management and prognostic markers. Australas J Dermatol. 2016; 57(3): 182-191.
13. Pope E, et al. Mycosis fungoides in the pediatric population: report from an international childhood registry of cutaneous lymphoma. J Cutan Med Surg. 2010; 14(1): 1-6.
14. Kikuchi A, Naka W, Harada T, Sakuraoka K, Harada R, Nishikawa T. Parapsoriasis in plaques: its potential for progression to malignant lymphoma. J Am Acad Dermatol. 1993; 29(3): 419-422.
15. Catalina Arsenescu Georgescu, Larisa Anghel. Long Term Assessment of The Biological Profile In Patients With Acute Myocardial Infarction And Left Bundle Branch Block. Rev. Chim 2017; 68(11):2682-2684.
16. Burg G, Dummer R, Nestle FO, Doebbeling U, Haeffner A. Cutaneous lymphomas consist of a spec-trum of nosologically different entities including mycosis fungoides and small plaque parapsoria-sis. Arch Dermatol 1996; 132(5): 567-572.
17. Belousova IE, Vanecek T, Samtsov AV, Michal M, Kazakov DV. A patient with clinicopathologic features of small plaque parapsoriasis presenting later with plaque-stage mycosis fungoides: report of a case and comparative retrospective study of 27 cases of "nonprogressive" small plaque parapsoriasis. J Am Acad Dermatol 2008; 59(3): 474-482.
18. Wilcox RA. Cutaneous T-cell lymphoma: 2016 update on diagnosis, risk-stratification, and management. Am J Hematol. 2016; 91(1): 151-165.
19. Koh MJ, Chong WS. Narrow -Band Ultraviolet B phototherapy for mycosis fungoides in children. Clin Exp Dermatol. 2014; 39(4): 474-478.
20. Gavrilovici C, Goldsmith DJ, Reid C, Gubeth-Tatomir P., Covic A. What is the role of ambulatory BP monitoring in pediatric nephrology? J Nephrol 2004; 17: 642-652.
21. Liviu Macovei, Răzvan Presură, Larisa Anghel, Bogdan Stanciu, Nicușor Lovin, Roberto Haret, Cătălina Arsenescu Georgescu. Coronary stent entrapment. Postep Kardiol Inter 2014; 103(37): 216-218.
22. Şalaru DL, Arsenescu-Georgescu C, Chatzikyrkou C, Karagiannis J, Fischer A, Mertens PR. Midkine, a heparin-binding growth factor, and its roles in atherogenesis and inflammatory kidney diseases. Nephrol Dial Transplant. 2016 May 17. pii: gfw083
23. Ouatu A, Tãnase DM, Floria M, Ionescu SD, Ambãruş V, Arsenescu-Georgescu C. Chronic kidney disease: Prognostic marker of nonfatal pulmonary thromboembolism. Anatol J Cardiol 2015; 15(11): 938-943.
24. Macovei L, Presura RM, Arsenescu Georgescu C. Systemic or local thrombolysis in high-risk pulmo-nary embolism. Cardiol J 2015; 22(4): 467-474.
25. Gavrilovici C., Oprea L. Clinical ethics, research ethics and community ethics-the moral triad of nowadays society. Rev Rom Bioetica 2013; 11: 3-5.
26. Roca, M., Mitu, O., Roca, I.C., Mitu, F., Chronic Diseases - Medical and Social Aspects. Revista de Cercetare si Interventie Sociala 2015; 49: 257-275.

Additional Files

Published

2018-04-04

Issue

Vol. 122 No. 1 (2018): The Medical-Surgical Journal

Section

INTERNAL MEDICINE - PEDIATRICS

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