ROLE OF COMPUTED TOMOGRAPHY IN THE EVALUATION OF THE PATIENTS WITH HEPATITIS C-RELATED LIVER CIRRHOSIS

Authors

  • F. MIHAI “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Anca TRIFAN “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • T. CUCIUREANU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • D. NEGRU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Ana-Maria SINGEAP “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Keywords:

CIRRHOSIS, HEPATITIS C VIRUS, COMPUTED TOMOGRAPHY, HEPATOCELLULAR CARCINOMA, MORPHOLOGICAL CHANGES OF LIVER

Abstract

Cirrhosis is an increasing cause of morbidity and mortality, one of the most common causes being hepatitis C virus (HCV) infection. Diagnosis, staging and complication assessment are equally important in patients’ management, as well as establishing the right indication for antiviral treatment and further follow-up.  So far, it is well recognized the role of multidetector computed tomography (MDCT) in the evaluation of focal liver lesions in the cirrhotic liver, while its capabilities of describing morphological changes of the liver and the extrahepatic response to increased portal pressure is less extensively used. The aim of this review is to underline the utility of MDCT as a useful complementary tool in the evaluation of patients with hepatitis C-related cirrhosis.

Author Biographies

  • F. MIHAI, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Surgery (I)

  • Anca TRIFAN, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Medical Specialties (I)

  • T. CUCIUREANU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Medical Specialties (I)

  • D. NEGRU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Surgery (I)

  • Ana-Maria SINGEAP, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Medical Specialties (I)

References

1. Schuppan D, Afdhal NH. Liver cirrhosis. Lancet 2008; 371: 838-851.
2. Sebastiani G, Gkouvatsos K, Pantopoulos K. Chronic hepatitis C and liver fibrosis. World J Gastro-enterol 2014; 20: 11033-11053.
3. Tsochatzis EA, Bosch J, Burroughs AK. Liver cirrhosis. Lancet 2014; 383: 1749-1761.
4. Cojocariu C-E, Trifan A-V, Gîrleanu I et al. Alcoholic liver disease--epidemiology and risk factors. Rev Med Chir Soc Med Nat Iasi 2014; 118: 910-917.
5. Mohd Hanafiah K, Groeger J, Flaxman AD, et al. Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to HCV seroprevalence. Hepatology 2013; 57: 1333-1342.
6. Rockey DC, Friedman SL. Hepatic Fibrosis and Cirrhosis. In: Zakim and Boyer’s Hepatology. Else-vier, 2012, 64-85.
7. Peter J, Nelson DR. Optimal Interferon ­ free Therapy in Treatment ­ experienced Chronic Hepatitis C Patients. Liver Int 2015; 1-7.
8. Rockey DC, Bissell DM. Noninvasive measures of liver fibrosis. Hepatology 2006; 43: 113-120.
9. Castera L. Noninvasive methods to assess liver disease in patients with hepatitis B or C. Gastroenter-ology 2012; 142: 1293-1302.
10. Nguyen D, Talwalkar JA. Noninvasive assessment of liver fibrosis. Hepatology 2011; 53: 2107-2110.
11. Huber A, Ebner L, Heverhagen JT, et al. State-of-the-art imaging of liver fibrosis and cirrhosis: A comprehensive review of current applications and future perspectives. Eur J Radiol Open 2015; 2: 90-100.
12. Cardoso H, Vale AM, Rodrigues S et al. High incidence of hepatocellular carcinoma following suc-cessful interferon-free antiviral therapy for hepatitis C associated cirrhosis. J Hepatol 2016; 65: 1070-1071.
13. Sangster GP, Previgliano CH, Nader M et al. MDCT Imaging Findings of Liver Cirrhosis: Spectrum of Hepatic and Extrahepatic Abdominal Complications. HPB Surg 2013; 2013: 1-12.
14. Tan KC. The right posterior hepatic notch sign. Radiology 2008; 248: 317-318.
15. Awaya H, Mitchell DG, Kamishima T et al. Cirrhosis: modified caudate-right lobe ratio. Radiology 2002; 224: 769-774.
16. Ito K, Mitchell DG, Kim MJ, et al. Right Posterior Hepatic Notch Sign: A Simple Diagnostic MR Finding of Cirrhosis. J Magn Reson Imaging 2003; 18: 561-566.
17. Gupta A, Kim DC, Krinsky G et al. CT and MRI of cirrhosis and its mimics. Am J Roentgenol 2004; 183: 1595-1601.
18. Ito K, Mitchell DG, Gabata T et al. Expanded gallbladder fossa: simple MR imaging sign of cirrhosis. Radiology 1999; 211: 723-726.
19. Harbin W, Robert N, Ferruccci J. Diagnosis of cirrhosis based on regional changes in hepatic mor-phology. Radiology 1980; 135: 273-283.
20. Huber A, Ebner L, Montani M et al. Computed tomography findings in liver fibrosis and cirrhosis. Swiss Med Wkly 2014; 144: 1-12.
21. Baron L, Ill GDD, Ill HO. Spectrum End-Stage of Imaging Cirrhosis: Part II, Focal Abnormalities. Am J Roentgenol 1999; 173: 1185-1192.
22. Dodd GD, Baron RL, Oliver JH et al. Spectrum of imaging findings of the liver in end-stage cirrhosis: part I, gross morphology and diffuse abnormalities. Am J Roentgenol 1999; 173: 1031-1036.
23. Smith AD, Branch CR, Zand K et al. Liver Surface Nodularity Quantification from Routine CT Images as a Biomarker for Detection and Evaluation of Cirrhosis. Radiology 2016; 280: 771-781.
24. Pickhardt PJ, Malecki K, Kloke J, et al. Accuracy of liver surface nodularity quantifcation on MDCT as a noninvasive biomarker for staging hepatic fibrosis. Am J Roentgenol 2016; 207: 1194-1199.
25. Kudo M, Zheng RQ, Kim SR, et al. Diagnostic accuracy of imaging for liver cirrhosis compared to histologically proven liver cirrhosis. Intervirology 2008; 51: 17-26.
26. Farooqui S, Ravendhran N, Cunningham SC. Early Hepatocellular Carcinoma: Diagnosing the Difficult Nodule. J Cancer Ther 2013; 4: 651-661.
27. Of R, Panel THE, The ON et al. Special Article Terminology of Nodular Hepatocellular Lesions. Hepatology 1995; 983-993.
28. Lim JH, Cho JM, Kim EY et al. Dysplastic nodules in liver cirrhosis: evaluation of hemodynamics with CT during arterial portography and CT hepatic arteriography. Radiology 2000; 214: 869-874.
29. Zamor PJ, deLemos AS, Russo MW. Viral hepatitis and hepatocellular carcinoma: etiology and man-agement. J Gastrointest Oncol 2017; 8: 229-242.
30. An C, Rakhmonova G, Choi J-Y et al. Liver imaging reporting and data system (LI-RADS) version 2014: understanding and application of the diagnostic algorithm. Clin Mol Hepatol 2016; 22: 296-307.
31. ***Liver Imaging Reporting and Data System (LI-RADS)-American College of Radiology-https://www.acr.org/Quality-Safety/Resources/LIRADS (accessed 20 May 2017).
32. Gîrleanu I, Trifan A, Cojocariu C et al. The risk of thrombotic events in patients with liver cirrhosis. Rev Med Chir Soc Med Nat Iasi 2014; 116: 991-996.
33. Kreuer S, Elgethun M, Tommack M. Imaging Findings of Cirrhosis. J Am Osteopath Coll Radiol 2016; 5: 5-13.
34. Karahan OI, Dodd GD, Chintapalli KN et al. Gastrointestinal wall thickening in patients with cirrhosis: frequency and patterns at contrast-enhanced CT. Radiology 2000; 215: 103-107.
35. Chopra S, Dodd GD, Chintapalli KN et al. Mesenteric, omental, and retroperitoneal edema in cirrhosis: frequency and spectrum of CT findings. Radiology 1999; 211: 737-742.

Additional Files

Published

2017-09-30

Issue

Vol. 121 No. 3 (2017): The Medical-Surgical Journal

Section

INTERNAL MEDICINE - PEDIATRICS

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