SERTRALINE INFLUENCE ON MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN RATS

Authors

  • Diana CIUBOTARIU University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi
  • M. NECHIFOR University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi

Abstract

Serotonine reuptake inhibitors are an important pharmacological arsenal for treating major depression, a severe disease with poorly understood pathogenic mechanisms. Also, little is known about the action of antidepressants on reward system, the function of which is severely affected in this disorder. Aim: To assess the influence of sertraline on brain reward system by conditioned place preference technique in rats. Results: Both 3 and 5 mg/kg doses of sertraline determined a significant rewarding effect, whereas only the 5 mg/kg dose increased the morphine-induced rewarding effect (in the morphine-only group time spent in the conditioning chamber increased by 184.92±21.43% post-conditioning vs. pre-conditioning, whereas the increase was 195.56±18.3% in the group treated with morphine and sertraline 5mg/kg, p<0.05). Conclusions: The stimulant effect of sertraline on brain reward function might be involved in its therapeutic efficacy.

Author Biographies

  • Diana CIUBOTARIU, University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi

    Faculty of Dental Medicine
    Discipline of  Pharmacology

  • M. NECHIFOR, University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi

    Faculty of Dental Medicine
    Discipline of  Pharmacology

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Additional Files

Published

2018-04-29

Issue

Vol. 118 No. 3 (2014): The Medical-Surgical Journal

Section

BASIC SCIENCES

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