CHARACTERISTICS OF CO INFECTION WITH HEPATITIS B VIRUS AMONG ROMANIAN PATIENTS INFECTED WITH HUMAN IMMUNODEFICIENCY VIRUS

Authors

  • Gabriela JUGANARIU University of Medicine and Pharmacy“Grigore T. Popa”-Iasi
  • Doina MIHALACHE University of Medicine and Pharmacy“Grigore T. Popa”-Iasi
  • Egidia MIFTODE University of Medicine and Pharmacy“Grigore T. Popa”-Iasi
  • Andra TEODOR University of Medicine and Pharmacy“Grigore T. Popa”-Iasi
  • D. TEODOR University of Medicine and Pharmacy“Grigore T. Popa”-Iasi
  • Carmen MANCIUC University of Medicine and Pharmacy“Grigore T. Popa”-Iasi
  • Carmen DOROBAT University of Medicine and Pharmacy“Grigore T. Popa”-Iasi

Abstract

Aim: To determine the epidemiological and viroimmunological features and outcome of HIV/HBV-co infected patients cared in the Iasi HIV/AIDS Regional Center. Material and Methods: This retrospective study included 252 patients diagnosed with HIV infection and associated hepatitis B virus (HBV) infection assessed at the Hospital of Infectious Diseases in the interval 2000-2013 and treated with antiretroviral drugs active against both HIV and HBV. Results: The prevalence of HIV/HBV co infection was 19.9%​. A slightly higher frequency of this co infection was found among males (53.2%); most patients belonged to age group 20-29 years (86.5%), mean age was 25.56 years. The predominant route of transmission was parenteral (58.5%), followed by heterosexual transmission (40.1%). The mean CD4 cell count was 246.20 cells/mm3, in over 41% of cases CD4 count ranging from 200 to 499 cells/mm3. The mean HIV plasma viral load was 142,906 copies/ml. ALT levels varied between 10-323 IU/l, average 49.90 IU/l, over 65% of subjects having pathological levels. In 21.8% of the cases, total cholesterol was very high, and in 16.8 % of the patients the serum triglyceride levels were below the reference range (160 mg %). Conclusions: Our results suggest that HIV-positive patients, chronic hepatitis B infection has a high incidence, especially in younger age groups and is correlated with significant degrees of immunosuppression.

Author Biographies

  • Gabriela JUGANARIU, University of Medicine and Pharmacy“Grigore T. Popa”-Iasi

    Faculty of Medicine
    Ph.D. student
    Discipline of Infectious Diseases

  • Doina MIHALACHE, University of Medicine and Pharmacy“Grigore T. Popa”-Iasi

    Faculty of Medicine
    Discipline of Infectious Diseases

  • Egidia MIFTODE, University of Medicine and Pharmacy“Grigore T. Popa”-Iasi

    Faculty of Medicine
    Discipline of Infectious Diseases

  • Andra TEODOR, University of Medicine and Pharmacy“Grigore T. Popa”-Iasi

    Faculty of Medicine
    Discipline of Infectious Diseases

  • D. TEODOR, University of Medicine and Pharmacy“Grigore T. Popa”-Iasi

    Faculty of Medicine
    Ph.D. student
    Discipline of Infectious Diseases

  • Carmen MANCIUC, University of Medicine and Pharmacy“Grigore T. Popa”-Iasi

    Faculty of Medicine
    Discipline of Infectious Diseases

  • Carmen DOROBAT, University of Medicine and Pharmacy“Grigore T. Popa”-Iasi

    Faculty of Medicine
    Discipline of Infectious Diseases

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Additional Files

Published

2018-05-02

Issue

Vol. 118 No. 2 (2014): The Medical-Surgical Journal

Section

INTERNAL MEDICINE - PEDIATRICS

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