PAIN MODULATION BY CURCUMIN AND ASCORBIC ACID IN MICE

Authors

  • A. LUCA University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi
  • Teodora ALEXA University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi
  • A. DONDAS Centre for the Study and Therapy of Pain
  • Georgiana ANDRON Centre for the Study and Therapy of Pain
  • Magda BADESCU University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi
  • Ioana Dana ALEXA University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi
  • Catalina BOHOTIN University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi

Abstract

Aim: The present study aims to evaluate whether ascorbic acid (AA) and curcumin, two substances with redox properties, have similar effects on different models of pain in mice. Materials and methods:  This study included a total of 28 mice that were divided into four groups. One group (AA) received intraperitoneally 500 mg/kg b.w. AA for 21 days and the 2-nd group (curcumin) received 120 mg/kg b.w. curcumin by gastric gavage for two weeks. Other two groups serve as control and received vehicle in a dose – time manner similar to that of the treated groups. The pain models (oro-facial formalin induced pain, paw formalin induced pain and visceral pain) were performed 24 h after the last dose. Results: when compared with control groups, curcumin significantly decreases pain perception in oro-facial (p=0.01 1-st phase, p=0.002 2-nd phase) and paw formalin induced pain (p=0.04 1-st and 2-nd phase) while AA stimulates pain perception in acid acetic induced visceral pain (p=0.05) and increases oro-facial inflammatory pain induced by formalin (p=0.02) but demonstrates analgesic effects on paw formalin induced pain (p=0.003 1-st phase, p=0.01 2-nd phase). Conclusions: ROS production is important in pain modulation. Structures involved in the process of pain have different antioxidant defense capacities. Curcumin and AA are able to modulate pain perception, but beside their antioxidant capacities, there are other mechanisms involved. 

Author Biographies

  • A. LUCA, University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi

    Faculty of Medicine
    Department of Pathophysiology
    Centre for the Study and Therapy of Pain

  • Teodora ALEXA, University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi

    Faculty of Medicine
    Department of Pathophysiology
    Centre for the Study and Therapy of Pain

  • Magda BADESCU, University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi

    Faculty of Medicine
    Department of Pathophysiology

  • Ioana Dana ALEXA, University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi

    Faculty of Medicine
    Discipline of Internal Medicine, Nephrology and Geriatrics

  • Catalina BOHOTIN, University of Medicine and Pharmacy “Grigore T. Popa” - Iaşi

    Faculty of Medicine
    Department of Pathophysiology
    Centre for the Study and Therapy of Pain

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Additional Files

Published

2018-05-03

Issue

Vol. 118 No. 2 (2014): The Medical-Surgical Journal

Section

INTERNAL MEDICINE - PEDIATRICS

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