THE IMPORTANCE OF RENAL BIOPSY IN THE MANAGEMENT OF RENAL TRANSPLANTATION

Authors

  • G. VEISA University of Medicine and Pharmacy "Grigore T. Popa"- Iași
  • C. Adelina-Iuliana BIRLESCU Clinical Hospital "Dr. CI Parhon" Iași
  • D. SIRIOPOL University of Medicine and Pharmacy "Grigore T. Popa"- Iași

Abstract

Renal biopsy remains the”gold standard’’ for the diagnosis of renal allograft dysfunction. The aim of our study was to highlight the importance of renal biopsy in the management of allograft dysfunction (early diagnosis and therapeutic approach). Our study included 23 renal allograft biopsies from 20 patients. This retrospective study analyzed the demographic and clinical data, histological results and the evolution of renal function under the immunosuppressive regimens. Conclusions: the most frequently encountered histopathological patterns were humoral rejection, interstitial fibrosis and chronic cellular rejection. Patients under continuous treatment with cyclosporine developed chronic cellular reject more frequently; on the opposite, patients under continuous treatment with tacrolimus developed chronic humoral reject more frequently.

Author Biographies

  • G. VEISA, University of Medicine and Pharmacy "Grigore T. Popa"- Iași

    Faculty of Medicine                                                                                                                                                    Discipline of Internal Medicine, Nephrology and Geriatrics

  • C. Adelina-Iuliana BIRLESCU, Clinical Hospital "Dr. CI Parhon" Iași

    Clinic of Nephrology

  • D. SIRIOPOL, University of Medicine and Pharmacy "Grigore T. Popa"- Iași

    Faculty of Medicine                                                                                                                                                      Discipline of Internal Medicine, Nephrology and Geriatrics

References

1. Chapman JR, O'Connell PJ, Nankivell BJ. Chronic renal allograft dysfunction. J Am SocNephrol. 2005; 16(10): 3015-3026.
2. Ahmad I. Biopsy of the transplanted kidney. SeminInterventRadiol. 2004; 21(4): 275-281.
3. Mazzali M, Ribeiro-Alves MA, AlvesFilho G. Percutaneous renal graft biopsy: a clinical, laboratory and pathological analysis. Sao Paulo Med J. 1999; 117(2): 57-62.
4. Parfrey PS, Kuo YL, Hanley JA, Knaack J, Xue Z, Lisbona R, Guttmann RD. The diagnostic and prognostic value of renal allograft biopsy. Transplantation. 1984; 38(6): 586-590.
5. Al-Awwa IA, Hariharan S, First MR. Importance of allograft biopsy in renal transplant recipients: correlation between clinical and histological diagnosis. Am J Kidney Dis. 1998; 31(6 Suppl 1): S15-18.
6. Kiss D, Landmann J, Mihatsch M, Huser B, Brunner FP, Thiel G. Risks and benefits of graft biopsy in renal transplantation under cyclosporin-A. ClinNephrol. 1992; 38(3): 132-134.
7. Sis B, Mengel M, Haas M et al. Banff '09 meeting report: antibody mediated graft deterioration and implementation of Banff working groups. Am J Transplant. 2010; 10(3): 464-471.

Additional Files

Published

2018-05-03

Issue

Vol. 118 No. 2 (2014): The Medical-Surgical Journal

Section

INTERNAL MEDICINE - PEDIATRICS

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