METABOLIC DISORDERS IN PATIENTS OPERATED FOR PANCREATIC CANCER

Authors

  • D. TIMOFTE University of Medicine and Pharmacy “Grigore T. Popa”-Iasi
  • Roxana LIVADARIU University of Medicine and Pharmacy “Grigore T. Popa”-Iasi
  • V. BINTINTAN University Hospital - Cluj-Napoca
  • C. DIACONU University of Medicine and Pharmacy “Grigore T. Popa”-Iasi
  • Lidia IONESCU University of Medicine and Pharmacy “Grigore T. Popa”-Iasi
  • A. A. SANDBERG Karolinska Huddinge Institute - Stockholm, Sweden
  • D. C. MARICIUC University of Medicine and Pharmacy “Grigore T. Popa”-Iasi
  • R. DANILA University of Medicine and Pharmacy “Grigore T. Popa”-Iasi

Abstract

Adenocarcinoma of the pancreas presents a major threat with a 5-years survival rate of 5%. Whipple pancreaticoduodenectomy (PD) is the standard procedure for cephalopancreatic neoplasm. After an extended resection and reconstruction of superior gastrointestinal tract the digestive physiology might be heavily disrupted. A literature review of metabolic alterations of patients who suffered a major pancreatic resection is performed, regarding micronutrients, lipid absorption and pancreatogenic diabetes. Long-term survivors following PD generally have a satisfactory nutritional status although with subclinical iron, vitamin D and selenium deficiency. These patients should be followed-up also regarding these micronutrients and properly dietary supplemented when necessary, also considering the increased life expectancy. Approximately 17-25% of patients will develop insulin-dependent diabetes but pancreatogenic diabetics have elevated levels of serum insulin and minimal or absent response to food intake, as opposed to a type I diabetics, where insulin serum is normal or elevated and there is an exaggerated response to ingestion of sugar.

Author Biographies

  • D. TIMOFTE, University of Medicine and Pharmacy “Grigore T. Popa”-Iasi

    Faculty of Medicine                                                                                                                                                          Department of IIIrd Surgery

  • Roxana LIVADARIU, University of Medicine and Pharmacy “Grigore T. Popa”-Iasi

    Faculty of Medicine                                                                                                                                                    Department of IIIrd Surgery
    Ph.D. student

  • V. BINTINTAN, University Hospital - Cluj-Napoca

    Department of Ist Surgery

  • C. DIACONU, University of Medicine and Pharmacy “Grigore T. Popa”-Iasi

    Faculty of Medicine                                                                                                                                                      Department of IIIrd Surgery

  • Lidia IONESCU, University of Medicine and Pharmacy “Grigore T. Popa”-Iasi

    Faculty of Medicine                                                                                                                                                      Department of IIIrd Surgery

  • A. A. SANDBERG, Karolinska Huddinge Institute - Stockholm, Sweden

    Department of Upper Gastrointestinal Surgery

  • D. C. MARICIUC, University of Medicine and Pharmacy “Grigore T. Popa”-Iasi

    Faculty of Medicine                                                                                                                                                          Department of IIIrd Surgery

  • R. DANILA, University of Medicine and Pharmacy “Grigore T. Popa”-Iasi

    Faculty of Medicine                                                                                                                                                    Department of IIIrd Surgery

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Additional Files

Published

2018-05-07

Issue

Vol. 118 No. 2 (2014): The Medical-Surgical Journal

Section

SURGERY

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