POSSIBILITIES TO ACYLATE 7-AMINOCEPHALOSPORANIC ACID TO OBTAIN SOME CEPHALOSPORINS

Authors

  • Catalina Daniela STAN University of Medicine and Pharmacy“Grigore T. Popa”- Iaşi
  • Maria DRAGAN University of Medicine and Pharmacy“Grigore T. Popa”- Iaşi
  • D. E. DIACONU Antibiotice S. A. – Iaşi
  • Alina STEFANACHE University of Medicine and Pharmacy“Grigore T. Popa”- Iaşi

Keywords:

7-AMINOCEPHALOSPORANIC ACID, CEFOTAXIME, CEPHALO-SPORINS, ACYLA-TION.

Abstract

Aim: Acylation of 7-aminocephalosporanic acid with an adequate acyl chloride in order to obtain cefotaxime sodium salt. Material and methods: Cefotaxime sodium salt was synthesized by acylating 7-amino cephalosporanic acid with 2-[2`-chloracetamidothiazole-4-yl]-2-(syn)-methoxy-imino acetic chloride in four steps. The melting point was determined, and IR spectral analysis and elemental analysis were performed to confirm cefotaxime structure. The quantitative determination was performed. Results: The reaction conditions were established. The yield of the synthesis phases (73-80%) and actual yield (45-47%) were very good. The structure of the obtained cefotaxime sodium salt was confirmed by the IR spectral analysis and by elemental analysis (C, H, N). The melting point was 1630C. The purity of the synthesized cefotaxime sodium salt was 98.9%. Conclusions: Cefotaxime sodium salt was synthesized by acylation of 7-aminocephalosporanic acid with 2-[2`-chloracetamidothiazole-4-yl]-2-(syn)-methoxy-imino acetic chloride, in aqueous solution, then transformed into sodium salt with sodium 2-ethylhexanoate. The method proved to be very good, yields were good, it is reproducible and simple, and does not involve high risks, so it is also safe.

Author Biographies

  • Catalina Daniela STAN, University of Medicine and Pharmacy“Grigore T. Popa”- Iaşi

    Faculty of Pharmacy
    Drug Industry and Pharmaceutical Biotechnology Department

  • Maria DRAGAN, University of Medicine and Pharmacy“Grigore T. Popa”- Iaşi

    Faculty of Pharmacy
    Drug Industry and Pharmaceutical Biotechnology Department

  • Alina STEFANACHE, University of Medicine and Pharmacy“Grigore T. Popa”- Iaşi

    Faculty of Pharmacy
    General and Innorganic Chemistry Department

References

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Additional Files

Published

2018-05-17