EVOLUTION OF BIOLOGICAL PARAMETERS IN THE METABOLIC SYNDROME
Keywords:
METABOLIC SYNDROME, CARDIOVASCULAR DISEASES, BIOLOGICAL PARAMETERS, PHARMACOLOGICAL THERAPYAbstract
The metabolic syndrome is responsible for the threefold increase of the atherosclerotic cardiovascular diseases and for the increase of the mortality due to these disorders compared to the general population. Aim: To evaluate the biochemistry dynamics and the specific medication in patients diagnosed with metabolic syndrome. Materials and methods: The study was carried out in the 3rd Medical Clinic of the “Sf. Spiridon” County Clinical Emergency Hospital of Iasi, being a retrospective study and including 250 patients which fulfilled at least three of the five defining criteria of the metabolic syndrome. Results: It was obtained the improvement of the inflammatory metabolic syndrome through the decrease of the fibrinogen and of the C-reactive protein (p=0.001). It was observed the fact that, both in men as well as in women, serum value of the uric acid proved to be significant in hypertensive subjects, a statistically significant decrease being observed in the patients treated with Candesartan. Conclusions: Obesity and especially the central adiposity is the dominant risk factor for the development of the type 2 diabetes mellitus, which usually is accompanied by the arterial hypertension due to a common physiopathology. Although the pharmacologic therapy is often necessary, a very important element remains the lifestyle change which represents the only full therapeutic approach which can reduce the resistance to insulin and visceral obesity.
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